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Guidelines

MIRAGE

inner centromere protein

Summary

Gene Symbol

INCENP

Organism

Homo sapiens (human)

External Links

NCBI Gene

3619

PubChem

3619

Alliance of Genome Resources

HGNC:6058

JoGo

INCENP

TogoVar

INCENP

Annotation

Keyword

3D-structure
Alternative splicing
Centromere
Chromosome
Chromosome partition
Cytoskeleton
Kinetochore
Microtubule
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NQS7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
mitotic cell cycle	NAS	17956729
mitotic cytokinesis	NAS	17956729
mitotic cytokinesis	IMP	16239925
mitotic cytokinesis	IBA
chromosome segregation	IMP	16239925

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle midzone assembly [inference]

cell cycle [inference]

mitotic cell cycle

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

chromosome segregation

spindle midzone assembly [inference]

meiotic cell cycle process [inference]

meiotic spindle midzone assembly

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

cellular component assembly [inference]

spindle midzone assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

reproductive process [inference]

meiotic cell cycle process [inference]

meiotic spindle midzone assembly

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

organelle localization [inference]

chromosome localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of localization [inference]

regulation of metaphase plate congression [inference]

regulation of attachment of mitotic spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

positive regulation of cell division [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

positive regulation of cell division [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of attachment of mitotic spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cell division [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of mitotic cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cytokinesis [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of mitotic cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of attachment of mitotic spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

regulation of chromosome separation [inference]

regulation of mitotic sister chromatid separation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of mitotic sister chromatid separation

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

regulation of attachment of mitotic spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

regulation of cell cycle phase transition [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
chromosome, centromeric region	IDA	11084331 16239925
kinetochore	IDA	16760428
kinetochore	IBA
lateral element	IEA
central element	IEA

GO Hierarchy

cellular component

protein-containing complex

microtubule associated complex [inference]

chromosome passenger complex

protein-DNA complex [inference]

chromatin [inference]

heterochromatin [inference]

pericentric heterochromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

chromocenter

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

chromocenter

spindle midzone [inference]

meiotic spindle midzone

chromosomal region [inference]

chromosome, centromeric region

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	14610074 16239925 17099693 17956729 19357306 20562864 20739936 21051298 21225229 21346195 27332895 29568061 30021884 32707033 33961781 35271311 9864353
molecular function activator activity	IPI	27332895

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

molecular function activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

inner centromere protein A

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cell cycle
cell division
chromosome segregation
meiotic spindle midzone assembly
metaphase chromosome alignment
mitotic cytokinesis

Displaying **all 2** entries
InterPro
Chromosome passenger complex (CPC) protein INCENP N-terminal
Inner centromere protein, ARK-binding domain

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Last updated: April 6, 2026