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inositol polyphosphate-5-phosphatase A

Summary

Gene Symbol

INPP5A

Aliases

43 kDa inositol polyphosphate 5-phophatase
5PTASE
CTCL tumor antigen HD-CL-02
InsP3 5-phosphatase
inositol polyphosphate 5-phophatase, 40kDa
type I inositol-1,4,5-trisphosphate 5-phosphatase

Organism

Homo sapiens (human)

External Links

NCBI Gene

3632

HGNC

6076

KEGG Gene ID

hsa:3632

PubChem

3632

Alliance of Genome Resources

HGNC:6076

Annotation

Keyword

Cell membrane
Cell projection
Hydrolase
Prenylation
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14642	43 kDa inositol polyphosphate 5-phosphatase Type I inositol 1,4,5-trisphosphate 5-phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
phosphatidylinositol dephosphorylation	IEA
inositol phosphate metabolic process

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
dendrite	ISS
plasma membrane	IDA TAS	8626616
membrane	IDA NAS	8006039

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying **all 5** entries
GO Term	Evidence Code	PMID
PH domain binding	IPI	8999861
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IEA
inositol-1,4,5-trisphosphate 5-phosphatase activity
protein binding	IPI	32296183 8999861
inositol-polyphosphate 5-phosphatase activity	IBA IDA NAS	8006039 8013665 8626616

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

inositol phosphate phosphatase activity [inference]

inositol trisphosphate phosphatase activity [inference]

inositol tetrakisphosphate phosphatase activity [inference]

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

binding [inference]

protein binding

protein domain specific binding [inference]

PH domain binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000068383

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01106

Name

inositol polyphosphate 5-phosphatase INPP5A [EC:3.1.3.56]

References

8198557

Rhea

RHEA:19797

H₂O + 1D-myo-inositol 1,4,5-trisphosphate

phosphate + 1D-myo-inositol 1,4-bisphosphate

Enzyme

3.1.3.56

PMID

RHEA:11392

H₂O + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

phosphate + 1D-myo-inositol 1,3,4-trisphosphate

Enzyme

3.1.3.56

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 19 in total

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Last »
DO ID	Disease Name	Source
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060643	primary sclerosing cholangitis	DisGeNET
DOID:1056	oculocerebrorenal syndrome	DisGeNET
DOID:11684	melanoacanthoma	DisGeNET
DOID:14268	sclerosing cholangitis	DisGeNET
DOID:14269	suppurative cholangitis	DisGeNET
DOID:14270	ascending cholangitis	DisGeNET
DOID:162	cancer	DisGeNET
DOID:1749	squamous cell carcinoma	DisGeNET
DOID:3149	keratoacanthoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002187
Gene Name: inositol polyphosphate-5-phosphatase, 40kDa

Ortholog

Displaying entry **81 - 81** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Strigops habroptila	115608073		STRHB04818

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements