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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
inositol polyphosphate phosphatase like 1
Summary
- Gene Symbol
-
- INPPL1
- Aliases
-
- 51C protein
- SH2 domain-containing inositol 5'-phosphatase 2
- SHIP2
- phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Actin-binding
- Alternative splicing
- Cell adhesion
- Cell membrane
- Cell projection
- Cytoskeleton
- Diabetes mellitus
- Disease variant
- Hydrolase
- Immunity
- Lipid metabolism
- Nucleus
- Phosphoprotein
- Reference proteome
- SH2 domain
- SH3-binding
- Proteins
| UniProt | Protein Name |
|---|---|
| O15357 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| post-embryonic development | ||
| negative regulation of gene expression | ||
| gene expression | ||
| response to insulin | ||
| ERK1 and ERK2 cascade |
GO Hierarchy
- immune system process
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| filopodium | ||
| cytosol | ||
| basal plasma membrane | ||
| nuclear speck |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | ||
| SH2 domain binding | ||
| actin binding | ||
| protein binding | ||
| SH3 domain binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0050635 | alternating hemiplegia of childhood | |
| DOID:0050775 | schneckenbecken dysplasia | |
| DOID:0060224 | atrial fibrillation | |
| DOID:0060249 | scoliosis | |
| DOID:0060849 | osteoporosis-pseudoglioma syndrome | |
| DOID:0060870 | isolated growth hormone deficiency | |
| DOID:0080001 | bone disease | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080348 | Alzheimer's disease 1 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001027 | Soft, doughy skin |
| HP:0001156 | Brachydactyly |
| HP:0001182 | Tapered finger |
| HP:0001231 | Abnormal fingernail morphology |
| HP:0001252 | Hypotonia |
| HP:0001270 | Motor delay |
| HP:0001290 | Generalized hypotonia |
| HP:0001387 | Joint stiffness |
| HP:0001538 | Protuberant abdomen |
| HP:0001561 | Polyhydramnios |
| Disease ID | Disease Name |
|---|---|
| ORPHA:3144 |
|
| ORPHA:2746 |
|
| OMIM:258480 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP001940
- Gene Name
- inositol polyphosphate phosphatase-like 1
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101121707 | SHEEP06473 | ||
| 105983930 | DIPOR06801 | ||
| 100772102 | CRIGR23386 | ||
| 16332 | MGI:1333787 | MOUSE56308 | |
| 65038 | RGD:68396 | RATNO17790 | |
| 100725170 | CAVPO22159 | ||
| 101585260 | OCTDE20158 | ||
| 103678107 | URSMA22169 | ||
| 113905536 | BOBOX34871 | ||
| 105860386 | MICMU08989 |
