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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
inositol polyphosphate phosphatase like 1
Summary
- Gene Symbol
-
- INPPL1
- Aliases
-
- 51C protein
- SH2 domain-containing inositol 5'-phosphatase 2
- SHIP2
- phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Actin-binding
- Alternative splicing
- Cell adhesion
- Cell membrane
- Cell projection
- Cytoskeleton
- Diabetes mellitus
- Disease variant
- Hydrolase
- Immunity
- Lipid metabolism
- Nucleus
- Phosphoprotein
- Reference proteome
- SH2 domain
- SH3-binding
- Proteins
| UniProt | Protein Name |
|---|---|
| O15357 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of actin filament organization |
|
|
| cell adhesion |
GO Hierarchy
- immune system process
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| filopodium | ||
| cytosol | ||
| basal plasma membrane | ||
| nuclear speck |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | ||
| SH2 domain binding | ||
| actin binding | ||
| protein binding | ||
| SH3 domain binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11383 | cryptorchidism | |
| DOID:11504 | autonomic neuropathy | |
| DOID:11716 | prediabetes syndrome | |
| DOID:11870 | Pick's disease | |
| DOID:12139 | dysthymic disorder | |
| DOID:1222 | cartilage disease | |
| DOID:1289 | neurodegenerative disease | |
| DOID:1324 | lung cancer | |
| DOID:14221 | abdominal obesity-metabolic syndrome 1 | |
| DOID:1443 | cerebral degeneration |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0003180 | Flat acetabular roof |
| HP:0003196 | Short nose |
| HP:0003311 | Hypoplasia of the odontoid process |
| HP:0003312 | Abnormal form of the vertebral bodies |
| HP:0003510 | Severe short stature |
| HP:0003577 | Congenital onset |
| HP:0004279 | Short palm |
| HP:0004565 | Severe platyspondyly |
| HP:0005019 | Diaphyseal undertubulation |
| HP:0005280 | Depressed nasal bridge |
| Disease ID | Disease Name |
|---|---|
| ORPHA:3144 |
|
| ORPHA:2746 |
|
| OMIM:258480 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP001940
- Gene Name
- inositol polyphosphate phosphatase-like 1
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 325179 | ZFIN:ZDB-GENE-030131-3904 | ||
| 103027088 | ASTMX04344 | ||
| 115163904 | SALTR99373 | ||
| 115561257 | GADMO18687 | ||
| 100705507 | ORENI16378 | ||
| 115569711 | SPAAU17266 | ||
| 108708768 | Xenbase:XB-GENE-6487464 | ||
| 100396447 | CALJA04607 | ||
| 105578792 | CERAT17507 | ||
| 718421 | MACMU10194 |
