inositol polyphosphate phosphatase like 1

Summary
Gene Symbol
  • INPPL1
Aliases
  • 51C protein
  • SH2 domain-containing inositol 5'-phosphatase 2
  • SHIP2
  • phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Organism
Homo sapiens (human)
External Links
NCBI Gene
3636
HGNC
6080
KEGG Gene ID
hsa:3636
PubChem
3636
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Actin-binding
  • Alternative splicing
  • Cell adhesion
  • Cell membrane
  • Cell projection
  • Cytoskeleton
  • Diabetes mellitus
  • Disease variant
  • Hydrolase
  • Immunity
  • Lipid metabolism
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • SH2 domain
  • SH3-binding
Proteins
Displaying 1 entry
UniProt Protein Name
O15357
  • Inositol polyphosphate phosphatase-like protein 1
  • Protein 51C
  • SH2 domain-containing inositol 5'-phosphatase 2
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000165458

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K15909
Name
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
References
Disease
Disease Ontology
Displaying entries 31 - 40 of 116 in total
DO ID Disease Name Source
DOID:0110749 type 1 diabetes mellitus 10
DOID:0110750 type 1 diabetes mellitus 11
DOID:0110751 type 1 diabetes mellitus 12
DOID:0110752 type 1 diabetes mellitus 13
DOID:0110753 type 1 diabetes mellitus 15
DOID:0110754 type 1 diabetes mellitus 17
DOID:0110755 type 1 diabetes mellitus 18
DOID:0110756 type 1 diabetes mellitus 19
DOID:0110757 type 1 diabetes mellitus 20
DOID:0110758 type 1 diabetes mellitus 21
The Human Phenotype Ontology
Displaying entries 1 - 10 of 83 in total
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0000028 Cryptorchidism
HP:0000117 Renal phosphate wasting
HP:0000175 Cleft palate
HP:0000239 Large fontanelles
HP:0000256 Macrocephaly
HP:0000268 Dolichocephaly
HP:0000272 Malar flattening
HP:0000316 Hypertelorism
HP:0000343 Long philtrum
Displaying all 3 entries
Disease ID Disease Name
ORPHA:3144
  • schneckenbecken dysplasia
ORPHA:2746
  • opsismodysplasia
OMIM:258480
  • opsismodysplasia
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001940
Gene Name
inositol polyphosphate phosphatase-like 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024