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myosin light chain 2

Summary

Gene Symbol

Myl2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

363925

PubChem

363925

Alliance of Genome Resources

RGD:1564245

Annotation

Keyword

Calcium
Cytoplasm
Metal-binding
Methylation
Muscle protein
Myosin
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P08733	Myosin light chain 2, slow skeletal/ventricular muscle isoform

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
negative regulation of cell growth	ISO
cardiac muscle contraction	IBA IDA IMP ISO	11448842 12002261 9409484
heart development	IBA ISO ISS
muscle cell development	ISO
muscle cell fate specification	IBA ISO

GO Hierarchy

biological process

cellular process [inference]

cell growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly [inference]

cardiac myofibril assembly

cellular developmental process [inference]

cell fate specification [inference]

muscle cell fate specification

cell development [inference]

muscle cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly [inference]

cardiac myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly [inference]

cardiac myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly [inference]

cardiac myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly [inference]

cardiac myofibril assembly

supramolecular fiber organization [inference]

myofibril assembly [inference]

cardiac myofibril assembly

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

circulatory system process [inference]

heart process [inference]

heart contraction

post-embryonic development

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly [inference]

cardiac myofibril assembly

anatomical structure development [inference]

cell development [inference]

muscle cell development

animal organ development [inference]

heart development

cellular developmental process [inference]

cell fate specification [inference]

muscle cell fate specification

cell development [inference]

muscle cell development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

developmental growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell growth

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cell growth

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction

positive regulation of the force of heart contraction

regulation of biological quality [inference]

regulation of the force of heart contraction

positive regulation of the force of heart contraction

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
myosin complex	IEA
myofibril	IBA IDA ISO	11448842
cardiac myofibril	ISO
A band	IEA
actin cytoskeleton	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

contractile fiber

myofibril

cardiac myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

contractile fiber

myofibril

cardiac myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber

myofibril

cardiac myofibril

Displaying **all 3** entries
GO Term	Evidence Code	PMID
actin monomer binding	ISO
calcium ion binding	IBA IEA ISO
structural constituent of muscle	ISO ISS

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of muscle

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding [inference]

actin monomer binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

myosin regulatory light chain 10

Functional Category

F: Nucleotide transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium ion binding
cardiac muscle contraction
metal ion binding
muscle cell fate specification

Displaying **all 3** entries
InterPro
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
myofibril	PMID:11448842
contractile muscle fiber	PMID:12002261 PMID:9409484

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080326	familial hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:0110316	hypertrophic cardiomyopathy 10	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **164** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4633		HGNC:7583	HUMAN15441
Mus musculus	17906	10090_1:0019ce	MGI:97272	MOUSE46441
Drosophila melanogaster	43587		FB:FBgn0002773
Sus scrofa	396690			PIGXX06827
Canis lupus familiaris	403614			CANLF10305
Pan troglodytes	452243			PANTR06914
Bos taurus	505519			BOVIN09505
Danio rerio	677750		ZFIN:ZDB-GENE-060331-137	DANRE42935
Macaca mulatta	711937			MACMU04152
Ornithorhynchus anatinus	100074559			ORNAN16172

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements