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silent information regulator 2

Summary

Gene Symbol

Tb927.7.1690

Organism

Trypanosoma brucei brucei TREU927

External Links

NCBI Gene: 3658380
PubChem: 3658380

Annotation

Keyword

Metal-binding
NAD
Nucleus
Reference proteome
Repressor
Telomere
Transcription regulation
Transferase
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q57V41	Regulatory protein SIR2 homolog 1 SIR2-related protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
DNA repair

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus
cytosol
cytoplasm
chromosome, telomeric region

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

chromosomal region [inference]

chromosome, telomeric region

Displaying **all 5** entries
GO Term	Evidence Code	PMID
NAD+ ADP-ribosyltransferase activity
NAD-dependent histone deacetylase activity	IEA	22301074
metal ion binding
histone deacetylase activity
NAD+ binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+ ADP-ribosyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

histone deacetylase activity

NAD-dependent histone deacetylase activity

deacetylase activity [inference]

protein lysine deacetylase activity [inference]

histone deacetylase activity

NAD-dependent histone deacetylase activity

NAD-dependent protein deacetylase activity [inference]

NAD-dependent histone deacetylase activity

catalytic activity, acting on a protein [inference]

protein lysine deacetylase activity [inference]

histone deacetylase activity

NAD-dependent histone deacetylase activity

NAD-dependent protein deacetylase activity [inference]

NAD-dependent histone deacetylase activity

histone modifying activity [inference]

histone deacetylase activity

NAD-dependent histone deacetylase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

ion binding [inference]

anion binding [inference]

NAD+ binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

H₂O + NAD⁺

nicotinamide + 2''-O-acetyl-ADP-D-ribose

Enzyme

2.3.1.286

PMID

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024