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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
integrin subunit alpha 2b
Summary
- Gene Symbol
-
- ITGA2B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cell adhesion
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Integrin
- Metal-binding
- Pyrrolidone carboxylic acid
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P08514 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cell-matrix adhesion | ||
| cell-cell adhesion | ||
| cell adhesion mediated by integrin | ||
| positive regulation of leukocyte migration | ||
| integrin-mediated signaling pathway |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| external side of plasma membrane | ||
| focal adhesion | ||
| plasma membrane | ||
| platelet alpha granule membrane | ||
| integrin complex |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| integrin binding | ||
| fibrinogen binding | ||
| extracellular matrix binding | ||
| metal ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- integrin
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
| Gene Ontology |
|---|
| cell adhesion mediated by integrin |
| cell-matrix adhesion |
| integrin binding |
| integrin-mediated signaling pathway |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060573 | von Willebrand's disease 1 | |
| DOID:0060574 | von Willebrand's disease 2 | |
| DOID:0060691 | platelet-type bleeding disorder 16 | |
| DOID:1059 | intellectual disability | |
| DOID:1588 | thrombocytopenia | |
| DOID:2219 | Glanzmann's thrombasthenia | |
| DOID:2945 | severe acute respiratory syndrome |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 16399 | MGI:96601 | MOUSE05378 | ||
| 32661 | FB:FBgn0001250 | |||
| 176240 | WB:WBGene00003929 | |||
| 403789 | CANLF18634 | |||
| 445380 | ZFIN:ZDB-GENE-051031-1 | DANRE30809 | ||
| 454730 | 9598_0:004368 | |||
| 495051 | Xenbase:XB-GENE-5950168 | |||
| 515011 | BOVIN13503 | |||
| 685269 | RGD:1596428 | RATNO02032 | ||
| 714955 | MACMU14144 |
