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Dystroglycan

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

36773

PubChem

36773

Alliance of Genome Resources

FB:FBgn0034072

Annotation

Keyword

Cytoskeleton
Nucleus
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0C4DHF6	Dystroglycan Dystrophin-associated glycoprotein 1
Q8WR08	Dystroglycan Dystrophin-associated glycoprotein 1
A1ZA89	Dystroglycan Dystrophin-associated glycoprotein 1
Q8STB9	Dystroglycan Dystrophin-associated glycoprotein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **21 - 21** of 21 in total

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GO Term	Evidence Code	PMID
regulation of synaptic activity	IMP	18385336

GO Hierarchy

biological process

cellular process [inference]

establishment or maintenance of cell polarity

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity

establishment or maintenance of epithelial cell apical/basal polarity

actin filament-based process [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

sarcomere organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

sarcomere organization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte axis specification

oocyte anterior/posterior axis specification

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

imaginal disc-derived wing vein specification

axis specification [inference]

oocyte axis specification

oocyte anterior/posterior axis specification

anterior/posterior axis specification [inference]

oocyte anterior/posterior axis specification

muscle attachment

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte axis specification

oocyte anterior/posterior axis specification

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

brain morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium

anatomical structure formation involved in morphogenesis [inference]

germarium-derived egg chamber formation

anatomical structure development [inference]

nerve development

growth [inference]

developmental growth [inference]

growth of a germarium-derived egg chamber

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of carbohydrate catabolic process [inference]

regulation of glycolytic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of cellular catabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycolytic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate catabolic process [inference]

regulation of glycolytic process

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic activity

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

regulation of cellular catabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycolytic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide catabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide catabolic process [inference]

regulation of glycolytic process

regulation of ATP metabolic process [inference]

regulation of glycolytic process

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
dystroglycan complex	ISS	10908592 11018515
dystroglycan complex	IDA	11502221
dystroglycan complex	IBA
membrane	IEA
Z disc	IDA	21256839

GO Hierarchy

cellular component

protein-containing complex [inference]

glycoprotein complex [inference]

dystrophin-associated glycoprotein complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

plasma membrane region [inference]

basal plasma membrane

Z disc

cell junction [inference]

synapse [inference]

neuromuscular junction

T-tubule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
laminin receptor activity	IDA	25232965
calcium ion binding	IEA
protein binding	IPI	17215867 17355978
structural constituent of muscle	ISS	11018515
laminin binding	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of muscle

binding [inference]

protein binding

laminin binding

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

laminin receptor activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

extracellular matrix binding [inference]

laminin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dystroglycan

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium ion binding
morphogenesis of an epithelium
muscle attachment
nerve development

Displaying **all 7** entries
InterPro
Alpha-dystroglycan N-terminal domain 2
Alpha-dystroglycan domain 2
Cadherin-like superfamily
DG-type SEA domain
Dystroglycan, C-terminal
Dystroglycan-type cadherin-like
Immunoglobulin-like fold

Alliance of Genome Resources

Expression

Displaying **all 9** entries
Location	References
sarcolemma	PMID:21256839
membrane	FB:FBrf0231198
neuromuscular junction	PMID:18446215
dystroglycan complex	PMID:11502221
plasma membrane	PMID:19317464 PMID:24231130
Z disc	PMID:21256839
T-tubule	PMID:17881734
axon	PMID:17215867 PMID:18820475
basal plasma membrane	PMID:17355978 PMID:19250553

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050453	lissencephaly	Alliance of Genome Resources
DOID:0112374	muscular dystrophy-dystroglycanopathy	Alliance of Genome Resources
DOID:9884	muscular dystrophy	Alliance of Genome Resources