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integrin subunit alpha L

Summary

Gene Symbol

ITGAL

Organism

Homo sapiens (human)

External Links

NCBI Gene

3683

PubChem

3683

Alliance of Genome Resources

HGNC:6148

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Host-virus interaction
Integrin
Magnesium
Metal-binding
Phagocytosis
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2RAL6
P20701	CD11 antigen-like family member A Leukocyte adhesion glycoprotein LFA-1 alpha chain Leukocyte function-associated molecule 1 alpha chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cell-matrix adhesion	IBA IMP NAS	19029120 19693543
cell-cell adhesion	IBA ISS	12652296
cell adhesion mediated by integrin	IBA
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	2477710
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP	2477710

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte migration [inference]

cellular extravasation [inference]

T cell extravasation [inference]

memory T cell extravasation

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration [inference]

T cell extravasation [inference]

memory T cell extravasation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell adhesion mediated by integrin

cell-cell adhesion

leukocyte cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

signal transduction

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

cellular extravasation [inference]

T cell extravasation [inference]

memory T cell extravasation

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration [inference]

T cell extravasation [inference]

memory T cell extravasation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
membrane	HDA	19946888
integrin alphaL-beta2 complex	IDA NAS	19029120 19693543
plasma membrane	TAS
integrin complex	IBA NAS	8103515

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphaL-beta2 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alphaL-beta2 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphaL-beta2 complex

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

specific granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

specific granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11544294 11812992 12208882 12526797 15946252 16595626 18985028 22956999 29100055
integrin binding	IBA
metal ion binding	IEA
ICAM-3 receptor activity	IMP	19029120
cell adhesion molecule binding	IMP IPI	1448173 19029120

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

ICAM-3 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

integrin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
cell adhesion mediated by integrin
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

Displaying **all 7** entries
InterPro
FG-GAP repeat
Integrin alpha beta-propellor
Integrin alpha chain
Integrin alpha, N-terminal
Integrin alpha, first immunoglubulin-like domain
Integrin alpha, second immunoglobulin-like domain
Integrin domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10952	nephritis	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 61 in total

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Species	Gene ID	Orthologous MAtrix
Capra hircus	102172115	CAPHI17030
Myotis lucifugus	102436734	MYOLU14920
Chlorocebus sabaeus	103231906	CHLSB14593
Carlito syrichta	103260120	CARSF26914
Ursus maritimus	103657863	URSMA26956
Nannospalax galili	103726419	NANGA16217
Rhinopithecus roxellana	104681602	RHIRO36819
Pteropus vampyrus	105304532	PTEVA03175
Macaca nemestrina	105483005	MACNE37122
Mandrillus leucophaeus	105541493	MANLE13879