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Guidelines

MIRAGE

integrin subunit beta 4

Summary

Gene Symbol

ITGB4

Organism

Homo sapiens (human)

External Links

NCBI Gene

3691

PubChem

3691

Alliance of Genome Resources

HGNC:6158

JoGo

ITGB4

TogoVar

ITGB4

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Epidermolysis bullosa
Glycoprotein
Integrin
Magnesium
Metal-binding
Palmitate
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7ZLD8
P16144	GP150

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 18** of 18 in total

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GO Term	Evidence Code	PMID
cell motility	IMP	19403692
trophoblast cell migration	IEA
cell-cell adhesion	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular process [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular developmental process [inference]

cell differentiation [inference]

mesodermal cell differentiation

ameboidal-type cell migration [inference]

trophoblast cell migration

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly [inference]

peripheral nervous system myelin formation

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell junction assembly [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

plasma membrane bounded cell projection organization [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

reproductive process [inference]

trophoblast cell migration

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skin morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly [inference]

peripheral nervous system myelin formation

anatomical structure development [inference]

nail development

cellular developmental process [inference]

cell differentiation [inference]

mesodermal cell differentiation

response to stimulus [inference]

response to stress [inference]

response to wounding

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying entries **11 - 15** of 15 in total

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GO Term	Evidence Code	PMID
hemidesmosome	IDA	12482924
cell leading edge	IDA	19403692
nuclear membrane	IDA
receptor complex	IDA	23382219
extracellular exosome	HDA	19199708

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

plasma membrane region [inference]

basal plasma membrane

anchoring junction [inference]

cell-substrate junction [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

cell leading edge

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	IPI	24851274
integrin binding	IBA
protein binding	IPI	10811835 11375975 12482924 19242489 19403692 20603614 21880726 24007983 24851274 25703379 2649503 27178753 32296183 33961781 35657344
insulin-like growth factor I binding	IDA	22351760
neuregulin binding	IDA	20682778

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

growth factor binding [inference]

insulin-like growth factor binding [inference]

insulin-like growth factor I binding

neuregulin binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

integrin beta-4

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cell adhesion mediated by integrin
cell communication
cell migration
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

Displaying entries **1 - 10** of 12 in total

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InterPro
CalX-like domain superfamily
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Integrin beta N-terminal
Integrin beta subunit, VWA domain
Integrin beta subunit, tail
Integrin beta subunit
Integrin beta tail domain superfamily
Integrin beta, epidermal growth factor-like domain 1

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060733	junctional epidermolysis bullosa with pyloric atresia	Alliance of Genome Resources
DOID:3209	junctional epidermolysis bullosa	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026