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STT3 oligosaccharyltransferase complex catalytic subunit A

Summary

Gene Symbol

STT3A

Aliases

MGC9042
STT3-A
TMC
dolichyl-diphosphooligosaccharide protein glycotransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

3703

HGNC

6172

KEGG Gene ID

hsa:3703

PubChem

3703

Alliance of Genome Resources

HGNC:6172

Annotation

Keyword

3D-structure
Alternative splicing
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Magnesium
Manganese
Metal-binding
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P46977	B5 Integral membrane protein 1 Transmembrane protein TMC

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein N-linked glycosylation	NAS	31831667
protein N-linked glycosylation	IMP	22467853
protein N-linked glycosylation via asparagine	ISS
protein N-linked glycosylation via asparagine	IDA	31296534 38670073
protein N-linked glycosylation via asparagine	IMP	19167329

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	NAS	31831667
endoplasmic reticulum membrane	TAS
oligosaccharyltransferase complex	ISS
oligosaccharyltransferase complex	NAS	31831667
oligosaccharyltransferase complex	TAS	19167329

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

endoplasmic reticulum protein-containing complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

catalytic complex [inference]

transferase complex [inference]

oligosaccharyltransferase complex

oligosaccharyltransferase III complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

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GO Term	Evidence Code	PMID
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	ISS
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IDA	31296534 38670073 39509507
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IMP	19167329 22467853
dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IBA
protein binding	IPI	21903422 30021884 32707033 32814053 33845483 35271311 36217030

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

oligosaccharyl transferase activity [inference]

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

subunit of the

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
dolichyl-diphosphooligosaccharide-protein glycotransferase activity
metal ion binding
oligosaccharyl transferase activity
post-translational protein modification
protein N-linked glycosylation via asparagine
transferase activity

Displaying **all 3** entries
InterPro
Oligosaccharyl transferase STT3, N-terminal domain
Oligosaccharyl transferase, STT3 subunit
STT3/PglB/AglB, core domain

KEGG BRITE Database

Orthology

K07151

Name

dolichyl-diphosphooligosaccharide---protein glycosyltransferase [EC:2.4.99.18]

References

12887896

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05976	2.4.99.18	G72079JG	G57930PW

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080572	congenital disorder of glycosylation Iw	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000046	Small scrotum
HP:0000054	Micropenis
HP:0000219	Thin upper lip vermilion
HP:0000252	Microcephaly
HP:0000256	Macrocephaly
HP:0000276	Long face
HP:0000303	Mandibular prognathia

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:615596	STT3A-congenital disorder of glycosylation
OMIM:619714	congenital disorder of glycosylation, type Iw, autosomal dominant
ORPHA:370921	STT3A-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003635
Gene Name: STT3A, subunit of the oligosaccharyltransferase complex (catalytic)

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements