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temporal expression: early

Summary

Gene Symbol

B19R

Organism

Vaccinia virus

External Links

NCBI Gene: 3707577
PubChem: 3707577

Annotation

Keyword

Disulfide bond
Early protein
Glycoprotein
Immunoglobulin domain
Inhibition of host interferon signaling pathway by virus
Receptor
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2Z2QB66

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
virus-mediated perturbation of host defense response
suppression by virus of host type I interferon-mediated signaling pathway
suppression of host innate immune response

GO Hierarchy

biological process

viral process [inference]

modulation by virus of host process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

modulation by symbiont of host process [inference]

modulation by virus of host process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

modulation by symbiont of host cellular process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

modulation by symbiont of host process [inference]

modulation by virus of host process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

modulation by symbiont of host cellular process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host [inference]

response to host defenses [inference]

perturbation of host defenses by symbiont [inference]

suppression of host defenses by symbiont [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to other organism [inference]

response to defenses of other organism [inference]

response to host defenses [inference]

perturbation of host defenses by symbiont [inference]

suppression of host defenses by symbiont [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host [inference]

response to host defenses [inference]

perturbation of host defenses by symbiont [inference]

suppression of host defenses by symbiont [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to defenses of other organism [inference]

response to host defenses [inference]

perturbation of host defenses by symbiont [inference]

suppression of host defenses by symbiont [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host [inference]

response to host defenses [inference]

perturbation of host defenses by symbiont [inference]

suppression of host defenses by symbiont [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to defenses of other organism [inference]

response to host defenses [inference]

perturbation of host defenses by symbiont [inference]

suppression of host defenses by symbiont [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host [inference]

response to host defenses [inference]

perturbation of host defenses by symbiont [inference]

suppression of host defenses by symbiont [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host innate immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

suppression by symbiont of host immune response [inference]

suppression of host innate immune response

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

perturbation by virus of host immune response [inference]

suppression by virus of host innate immune response [inference]

suppression of host interferon-mediated signaling pathway [inference]

suppression by virus of host type I interferon-mediated signaling pathway

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying 1 entry
GO Term	Evidence Code	PMID
receptor decoy activity

GO Hierarchy

molecular function

molecular sequestering activity [inference]

receptor decoy activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Viruses

Group Name

Immunoglobulin

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis

Displaying 1 entry
Gene Ontology
symbiont-mediated suppression of host type I interferon-mediated signaling pathway

Displaying **all 5** entries
InterPro
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Interleukin-1 receptor family

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Last updated: April 6, 2026

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Acknowledgements