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temporal expression: early

Summary

Gene Symbol

M2L

Organism

Vaccinia virus

External Links

NCBI Gene: 3707646
PubChem: 3707646

Annotation

Keyword

Early protein
Glycoprotein
Host endoplasmic reticulum
Inhibition of host NF-kappa-B by virus
Reference proteome
Secreted
Signal
Viral immunoevasion

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q1PJ18	Protein M2
Q80HY2	Protein M2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
virus-mediated perturbation of host defense response
suppression of host T-cell mediated immune response
symbiont-mediated suppression of host canonical NF-kappaB cascade

GO Hierarchy

biological process

viral process [inference]

modulation by virus of host process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

modulation by symbiont of host process [inference]

modulation by virus of host process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

modulation by symbiont of host cellular process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

perturbation of host signal transduction pathway [inference]

symbiont-mediated suppression of host signal transduction pathway [inference]

symbiont-mediated suppression of host canonical NF-kappaB cascade

pertubation of host canonical NF-kappaB cascade [inference]

symbiont-mediated suppression of host canonical NF-kappaB cascade

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of signal transduction in another organism [inference]

perturbation of host signal transduction pathway [inference]

symbiont-mediated suppression of host signal transduction pathway [inference]

symbiont-mediated suppression of host canonical NF-kappaB cascade

pertubation of host canonical NF-kappaB cascade [inference]

symbiont-mediated suppression of host canonical NF-kappaB cascade

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

modulation by symbiont of host process [inference]

modulation by virus of host process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

modulation by symbiont of host cellular process [inference]

modulation by virus of host cellular process [inference]

virus-mediated perturbation of host defense response

perturbation of host signal transduction pathway [inference]

symbiont-mediated suppression of host signal transduction pathway [inference]

symbiont-mediated suppression of host canonical NF-kappaB cascade

pertubation of host canonical NF-kappaB cascade [inference]

symbiont-mediated suppression of host canonical NF-kappaB cascade

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host [inference]

response to host defenses [inference]

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to other organism [inference]

response to defenses of other organism [inference]

response to host defenses [inference]

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host [inference]

response to host defenses [inference]

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to defenses of other organism [inference]

response to host defenses [inference]

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host [inference]

response to host defenses [inference]

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to defenses of other organism [inference]

response to host defenses [inference]

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host [inference]

response to host defenses [inference]

symbiont-mediated perturbation of host defense response [inference]

virus-mediated perturbation of host defense response

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

response to host immune response [inference]

symbiont-mediated perturbation of host immune response [inference]

perturbation of host cell-mediated immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

perturbation of host T-cell mediated immune response [inference]

suppression of host T-cell mediated immune response

suppression by symbiont of host immune response [inference]

suppression by symbiont of host cell-mediated immune response [inference]

suppression of host T-cell mediated immune response

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space
host cell endoplasmic reticulum

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

host cellular component [inference]

host cell part [inference]

host intracellular part [inference]

host intracellular organelle [inference]

host intracellular membrane-bounded organelle [inference]

host cell endoplasmic reticulum

host cell cytoplasm part [inference]

host cell endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
protein sequestering activity

GO Hierarchy

molecular function

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level: Viruses
Group Name: Poxvirus M2

Displaying 1 entry
InterPro
Poxvirus M2

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025

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Acknowledgements