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jagged canonical Notch ligand 2

Summary

Gene Symbol

JAG2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3714

PubChem

3714

Alliance of Genome Resources

HGNC:6189

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Developmental protein
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Limb-girdle muscular dystrophy
Notch signaling pathway
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y219

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
morphogenesis of embryonic epithelium	IEA
regulation of cell adhesion	IEA
T cell differentiation	IDA	10383933
Notch signaling pathway	NAS	11056013
positive regulation of Notch signaling pathway	ISS

GO Hierarchy

biological process

immune system process [inference]

T cell selection [inference]

thymic T cell selection

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

T cell activation [inference]

T cell differentiation

gamma-delta T cell differentiation

gamma-delta T cell activation [inference]

gamma-delta T cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

T cell activation [inference]

T cell differentiation

gamma-delta T cell differentiation

gamma-delta T cell activation [inference]

gamma-delta T cell differentiation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

apoptotic process involved in development [inference]

apoptotic process involved in morphogenesis [inference]

epithelial cell apoptotic process involved in palatal shelf morphogenesis

epithelial cell apoptotic process [inference]

epithelial cell apoptotic process involved in palatal shelf morphogenesis

cellular developmental process [inference]

cell differentiation

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

cell fate commitment [inference]

neuron fate commitment [inference]

inner ear receptor cell fate commitment [inference]

auditory receptor cell fate commitment

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

T cell activation [inference]

T cell differentiation

gamma-delta T cell differentiation

gamma-delta T cell activation [inference]

gamma-delta T cell differentiation

system process [inference]

respiratory system process

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

cell fate commitment [inference]

neuron fate commitment [inference]

inner ear receptor cell fate commitment [inference]

auditory receptor cell fate commitment

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	ISS TAS	10910909

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16713569
Notch binding	IBA IPI	9315665
calcium ion binding	IEA
growth factor activity	IDA	10383933

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

Notch binding

receptor ligand activity [inference]

growth factor activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Notch

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 4** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110274	autosomal recessive limb-girdle muscular dystrophy	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16450		MGI:1098270	MOUSE09791
Rattus norvegicus	29147		RGD:2938	RATNO36910
Drosophila melanogaster	43275		FB:FBgn0004197
Danio rerio	140422		ZFIN:ZDB-GENE-011128-3	DANRE48583
Pan troglodytes	453210	9598_0:003af0
Danio rerio	566455		ZFIN:ZDB-GENE-130530-549
Macaca mulatta	699003			MACMU40036
Macaca mulatta	708991			MACMU40036
Monodelphis domestica	100014054			MONDO05258
Equus caballus	100063598			HORSE22927