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5-hydroxytryptamine (serotonin) receptor 1A

Summary

Gene Symbol

5-HT1A

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

37196

PubChem

37196

Alliance of Genome Resources

FB:FBgn0004168

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P28285	Serotonin receptor 2A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
inter-male aggressive behavior	IMP	24830553
G protein-coupled receptor signaling pathway	IEA
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting serotonin receptor signaling pathway	TAS	11282322
adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA	1310937

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

serotonin receptor signaling pathway

reproductive process [inference]

reproductive behavior [inference]

mating behavior [inference]

courtship behavior [inference]

male courtship behavior

male mating behavior [inference]

male courtship behavior

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory [inference]

anesthesia-resistant memory

behavior [inference]

aggressive behavior [inference]

inter-male aggressive behavior

learning or memory [inference]

memory [inference]

anesthesia-resistant memory

reproductive behavior [inference]

mating behavior [inference]

courtship behavior [inference]

male courtship behavior

male mating behavior [inference]

male courtship behavior

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of circadian rhythm [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

serotonin receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
membrane	ISS	10908591
membrane	IEA
dendrite	IBA
synapse

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
Gi/o-coupled serotonin receptor activity	NAS	11282322
G protein-coupled receptor activity	IEA
G protein-coupled serotonin receptor activity	ISS	10908591
G protein-coupled serotonin receptor activity	TAS	11282322
G protein-coupled serotonin receptor activity	IDA	23817146

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled amine receptor activity

G protein-coupled serotonin receptor activity

Gi/o-coupled serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
membrane	FB:FBrf0231198

Ortholog

Displaying entries **1 - 10** of 15 in total

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Species	Gene ID	Alliance of Genome Resources
Danio rerio	3350	ZFIN:ZDB-GENE-090409-2
Xenopus tropicalis	3351	Xenbase:XB-GENE-988006
Homo sapiens	3352	HGNC:5289
Xenopus tropicalis	3354	Xenbase:XB-GENE-965113
Caenorhabditis elegans	3355	WB:WBGene00004779
Danio rerio	15550	ZFIN:ZDB-GENE-090409-2
Xenopus tropicalis	15551	Xenbase:XB-GENE-988006
Homo sapiens	15552	HGNC:5289
Caenorhabditis elegans	15557	WB:WBGene00004779
Danio rerio	24473	ZFIN:ZDB-GENE-090409-2

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LM-GlycoRepo

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Acknowledgements