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low density lipoprotein receptor S homeolog

Summary

Gene Symbol

ldlr.S

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

373644

PubChem

373644

Alliance of Genome Resources

Xenbase:XB-GENE-962375

Annotation

Keyword

Cholesterol metabolism
Coated pit
Disulfide bond
EGF-like domain
Endocytosis
Glycoprotein
LDL
Lipid transport
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99088

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
receptor-mediated endocytosis involved in cholesterol transport	IEA
cholesterol metabolic process	IEA
endocytosis	IEA
cholesterol homeostasis	IEA
lipid transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis involved in cholesterol transport

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

organic substance transport [inference]

lipid transport

import into cell [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis involved in cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

Displaying **all 4** entries
GO Term	Evidence Code	PMID
early endosome	IEA
plasma membrane	IEA
low-density lipoprotein particle	IEA
clathrin-coated pit	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
low-density lipoprotein particle receptor activity	IEA
lipoprotein particle binding	IEA
calcium ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding

cargo receptor activity [inference]

lipoprotein particle receptor activity [inference]

low-density lipoprotein particle receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Low-density lipoprotein receptor

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 8** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
LDL receptor-like superfamily
LDLR class B repeat
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Six-bladed beta-propeller, TolB-like

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:12783	migraine without aura	Alliance of Genome Resources
DOID:13810	familial hypercholesterolemia	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of **106** in total

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Species	Gene ID	OrthoDB
Myotis davidii	102771350	225400_0:002480
Chrysochloris asiatica	102820233	185453_0:004293
Elephantulus edwardii	102862094	28737_0:003fd3
Peromyscus maniculatus bairdii	102906007	230844_0:002642
Physeter catodon	102984457	9755_0:004c09
Cricetulus griseus	103159831	10029_0:00374d
Orycteropus afer afer	103207932	1230840_0:003b1f
Carlito syrichta	103271413	1868482_0:003f30
Galeopterus variegatus	103591348	482537_0:001af1
Ursus maritimus	103678713	29073_0:000ffa

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements