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Guidelines

MIRAGE

natural killer cell cytotoxicity receptor 3 ligand 1

Summary

Gene Symbol

NCR3LG1

Organism

Homo sapiens (human)

External Links

NCBI Gene

374383

PubChem

374383

Alliance of Genome Resources

HGNC:42400

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q68D85	B7 homolog 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
complement activation, classical pathway
signal transduction	IEA
antibacterial humoral response
NK T cell activation	IDA	19528259

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, classical pathway

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

antimicrobial humoral response [inference]

antibacterial humoral response

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

alpha-beta T cell activation [inference]

NK T cell activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

alpha-beta T cell activation [inference]

NK T cell activation

signal transduction

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

alpha-beta T cell activation [inference]

NK T cell activation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

antimicrobial humoral response [inference]

antibacterial humoral response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of cellular process [inference]

signal transduction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	19528259
immunoglobulin complex, circulating

GO Hierarchy

cellular component

protein-containing complex [inference]

immunoglobulin complex [inference]

immunoglobulin complex, circulating

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
antigen binding
protein binding	IPI	19528259 21422170 21444796 22807449 24275655 27754869 32296183
immunoglobulin receptor binding
receptor ligand activity	IDA	19528259

GO Hierarchy

molecular function

binding [inference]

antigen binding

protein binding

signaling receptor binding [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Natural cytotoxicity triggering receptor 3 ligand 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
InterPro
Immunoglobulin C1-set
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Immunoglobulin/major histocompatibility complex, conserved site

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	374383	Xenbase:XB-GENE-5969034
Pongo abelii	100171423		PONAB03632
Nomascus leucogenys	100600410		NOMLE10679
Macaca fascicularis	102121659		MACFA09420
Chlorocebus sabaeus	103239555		CHLSB00621

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025