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potassium voltage-gated channel subfamily C member 2

Summary

Gene Symbol

KCNC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3747

PubChem

3747

Alliance of Genome Resources

HGNC:6234

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Chromosomal rearrangement
Disease variant
Epilepsy
Glycoprotein
Intellectual disability
Metal-binding
Phosphoprotein
Postsynaptic cell membrane
Potassium channel
Proteomics identification
Reference proteome
Synapse
Synaptosome
Transmembrane helix
Voltage-gated channel
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q96PR1	Potassium voltage-gated channel subfamily C member 2 Shaw-like potassium channel Voltage-gated potassium channel Kv3.2
A0A3B3ISR9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
action potential	IBA
potassium ion transport	IDA	15709110 32392612 36090251
response to light intensity	IEA
response to organic cyclic compound
response to amine	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

nitric oxide mediated signal transduction [inference]

nitric oxide-cGMP-mediated signaling pathway

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling [inference]

nitric oxide-cGMP-mediated signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

cellular response to toxic substance

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

developmental process [inference]

anatomical structure development [inference]

nerve development [inference]

cranial nerve development [inference]

optic nerve development

neural nucleus development [inference]

globus pallidus development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to light intensity

response to endogenous stimulus [inference]

response to growth factor [inference]

response to nerve growth factor

response to chemical [inference]

response to toxic substance [inference]

cellular response to toxic substance

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine

response to organic cyclic compound

response to alcohol [inference]

response to ethanol

response to inorganic substance [inference]

response to metal ion [inference]

response to magnesium ion

response to ammonium ion [inference]

cellular response to ammonium ion

cellular response to inorganic substance [inference]

cellular response to nitric oxide

response to nitric oxide [inference]

cellular response to nitric oxide

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

cellular response to toxic substance

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine

response to ammonium ion [inference]

cellular response to ammonium ion

response to nitric oxide [inference]

cellular response to nitric oxide

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

response to oxygen-containing compound [inference]

response to nitric oxide [inference]

cellular response to nitric oxide

response to alcohol [inference]

response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

cellular response to toxic substance

cellular response to nitrogen compound [inference]

cellular response to ammonium ion

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

nitric oxide mediated signal transduction [inference]

nitric oxide-cGMP-mediated signaling pathway

cyclic-nucleotide-mediated signaling [inference]

cGMP-mediated signaling [inference]

nitric oxide-cGMP-mediated signaling pathway

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of action potential [inference]

regulation of action potential firing rate

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of action potential [inference]

regulation of action potential firing rate

regulation of presynaptic membrane potential

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	TAS
voltage-gated potassium channel complex	ISS
voltage-gated potassium channel complex	IBA
membrane	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

synaptic membrane [inference]

cell junction [inference]

synapse

GABA-ergic synapse

leading edge membrane [inference]

neuron projection membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle

cell body

cell body membrane [inference]

neuronal cell body membrane

neuron projection terminus [inference]

axon terminus

presynapse [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
voltage-gated potassium channel activity	ISS
voltage-gated potassium channel activity	IDA	15709110 32392612 36090251
delayed rectifier potassium channel activity	ISS
delayed rectifier potassium channel activity	IBA
transmembrane transporter binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

binding [inference]

protein binding [inference]

transmembrane transporter binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Potassium channel

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
delayed rectifier potassium channel activity
monoatomic ion channel activity
monoatomic ion transport
potassium channel activity
protein homooligomerization
voltage-gated potassium channel activity

Displaying **all 6** entries
InterPro
BTB/POZ domain
Ion transport domain
Potassium channel tetramerisation-type BTB domain
Potassium channel, voltage dependent, Kv
SKP1/BTB/POZ domain superfamily
Voltage-dependent channel domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070389	developmental and epileptic encephalopathy 103	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements