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potassium inwardly rectifying channel subfamily J member 3

Summary

Gene Symbol

KCNJ3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3760

PubChem

3760

Alliance of Genome Resources

HGNC:6264

Annotation

Keyword

Alternative splicing
Glycoprotein
Phosphoprotein
Potassium transport
Reference proteome
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 3** entries
UniProt	Protein Name
D2X9V0	Inward rectifier K(+) channel Kir3.1 Potassium channel, inwardly rectifying subfamily J member 3
P48549	Inward rectifier K(+) channel Kir3.1 Potassium channel, inwardly rectifying subfamily J member 3
D2XBF0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
potassium ion transport	TAS	8804710
regulation of monoatomic ion transmembrane transport	IBA
regulation of ion transmembrane transport	IBA
response to electrical stimulus	IEA
potassium ion transmembrane transport	NAS	19703462

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

response to stimulus [inference]

response to abiotic stimulus [inference]

response to electrical stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of ion transmembrane transport

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

membrane repolarization [inference]

membrane repolarization during action potential [inference]

membrane repolarization during cardiac muscle cell action potential [inference]

cardiac muscle cell membrane repolarization [inference]

membrane repolarization during cardiac muscle cell action potential [inference]

atrial cardiac muscle cell membrane repolarization [inference]

membrane repolarization during atrial cardiac muscle cell action potential

ventricular cardiac muscle cell membrane repolarization

membrane repolarization during ventricular cardiac muscle cell action potential

regulation of presynaptic membrane potential

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
voltage-gated potassium channel complex	IDA	20560207
external side of plasma membrane	IEA
T-tubule	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

inward rectifier potassium channel complex [inference]

I(KACh) inward rectifier potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

inward rectifier potassium channel complex [inference]

I(KACh) inward rectifier potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

inward rectifier potassium channel complex [inference]

I(KACh) inward rectifier potassium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

T-tubule

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
inward rectifier potassium channel activity	IDA	12297500 20560207
protein binding	IPI	12297500
phosphatidylinositol-4,5-bisphosphate binding	ISS
G-protein activated inward rectifier potassium channel activity	IDA	8804710 8868049
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	IC	20560207

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

g protein-activated inward rectifier potassium

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
inward rectifier potassium channel activity
monoatomic ion transport
regulation of monoatomic ion transmembrane transport

Displaying **all 6** entries
InterPro
Immunoglobulin E-set
Inward rectifier potassium channel, C-terminal
Potassium channel, inwardly rectifying, Kir, cytoplasmic
Potassium channel, inwardly rectifying, Kir3.1
Potassium channel, inwardly rectifying, Kir
Potassium channel, inwardly rectifying, transmembrane domain

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3760	Xenbase:XB-GENE-1004371
Drosophila melanogaster	3762	FB:FBgn0265042
Drosophila melanogaster	3767	FB:FBgn0265042
Drosophila melanogaster	16514	FB:FBgn0265042
Mus musculus	16519	Xenbase:XB-GENE-1004371	MOUSE36239
Rattus norvegicus	50599	Xenbase:XB-GENE-1004371	RATNO27809
Drosophila melanogaster	83535	FB:FBgn0265042
Canis lupus familiaris	488355		CANLF13881
Bos taurus	526088		BOVIN24244
Macaca mulatta	696473		MACMU07092