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potassium inwardly rectifying channel subfamily J member 5

Summary

Gene Symbol

KCNJ5

Organism

Homo sapiens (human)

External Links

NCBI Gene

3762

PubChem

3762

Alliance of Genome Resources

HGNC:6266

Annotation

Keyword

Disease variant
Long QT syndrome
Phosphoprotein
Potassium transport
Reference proteome
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A5J6E2W8	Cardiac inward rectifier Heart KATP channel Inward rectifier K(+) channel Kir3.4 KATP-1 Potassium channel, inwardly rectifying subfamily J member 5
P48544	Cardiac inward rectifier Heart KATP channel Inward rectifier K(+) channel Kir3.4 KATP-1 Potassium channel, inwardly rectifying subfamily J member 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
potassium ion transport	TAS	8834003
regulation of monoatomic ion transmembrane transport	IBA
regulation of ion transmembrane transport	IBA
potassium ion transmembrane transport	NAS	19703462
regulation of heart rate by cardiac conduction	IMP	20560207

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of ion transmembrane transport

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of ion transmembrane transport

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

membrane repolarization [inference]

membrane repolarization during action potential [inference]

membrane repolarization during cardiac muscle cell action potential [inference]

cardiac muscle cell membrane repolarization [inference]

membrane repolarization during cardiac muscle cell action potential [inference]

atrial cardiac muscle cell membrane repolarization [inference]

membrane repolarization during atrial cardiac muscle cell action potential

ventricular cardiac muscle cell membrane repolarization

membrane repolarization during ventricular cardiac muscle cell action potential

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
voltage-gated potassium channel complex	IDA	20560207
I(KACh) inward rectifier potassium channel complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

inward rectifier potassium channel complex [inference]

I(KACh) inward rectifier potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

inward rectifier potassium channel complex [inference]

I(KACh) inward rectifier potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

inward rectifier potassium channel complex [inference]

I(KACh) inward rectifier potassium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
inward rectifier potassium channel activity	IDA	12297500 20560207
inward rectifier potassium channel activity	IMP	22628607 24037882 27099398 27293068 8558261
inward rectifier potassium channel activity	IBA
protein binding	IPI	12297500 32296183
G-protein activated inward rectifier potassium channel activity	TAS	8834003

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

inward rectifier potassium channel activity

G-protein activated inward rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G protein-activated inward rectifier potassium channel 2

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
inward rectifier potassium channel activity
monoatomic ion transport
regulation of monoatomic ion transmembrane transport

Displaying **all 5** entries
InterPro
Immunoglobulin E-set
Inward rectifier potassium channel, C-terminal
Potassium channel, inwardly rectifying, Kir, cytoplasmic
Potassium channel, inwardly rectifying, Kir
Potassium channel, inwardly rectifying, transmembrane domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060224	atrial fibrillation	Alliance of Genome Resources
DOID:0110654	long QT syndrome 13	Alliance of Genome Resources
DOID:446	primary hyperaldosteronism	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3760	FB:FBgn0265042
Xenopus tropicalis	3762	Xenbase:XB-GENE-5906252
Drosophila melanogaster	3767	FB:FBgn0265042
Drosophila melanogaster	16514	FB:FBgn0265042
Drosophila melanogaster	16519	FB:FBgn0265042
Mus musculus	16521		MOUSE60793
Rattus norvegicus	29713		RATNO40830
Drosophila melanogaster	50599	FB:FBgn0265042
Drosophila melanogaster	83535	FB:FBgn0265042
Sus scrofa	397448		PIGXX35774

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Acknowledgements