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Guidelines

MIRAGE

potassium voltage-gated channel subfamily Q member 3

Summary

Gene Symbol

KCNQ3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3786

PubChem

3786

Alliance of Genome Resources

HGNC:6297

JoGo

KCNQ3

TogoVar

KCNQ3

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Epilepsy
Phosphoprotein
Potassium channel
Proteomics identification
Reference proteome
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O43525	KQT-like 3 Potassium channel subunit alpha KvLQT3 Voltage-gated potassium channel subunit Kv7.3
E7ET42

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **26 - 27** of 27 in total

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GO Term	Evidence Code	PMID
regulation of action potential firing threshold	IEA
substantia propria of cornea development	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

vesicle-mediated transport [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein targeting

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

apoptosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

apoptosome assembly

export from cell [inference]

secretion by cell [inference]

exocytosis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

behavior [inference]

motor behavior [inference]

psychomotor behavior

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

anatomical structure development [inference]

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

response to organic substance [inference]

response to organic cyclic compound

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to xenobiotic stimulus

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein targeting

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

vesicle-mediated transport [inference]

secretion [inference]

secretion by cell [inference]

exocytosis

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

import into cell [inference]

endocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis

establishment of protein localization [inference]

protein targeting

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein targeting

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of action potential [inference]

regulation of action potential firing threshold

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential [inference]

regulation of mitochondrial membrane potential [inference]

mitochondrial depolarization

membrane depolarization [inference]

mitochondrial depolarization

membrane hyperpolarization

regulation of action potential [inference]

regulation of action potential firing threshold

regulation of synaptic plasticity

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
mitochondrion	IEA
plasma membrane	ISS	16525039
plasma membrane	TAS
plasma membrane	IDA	10788442 11159685
voltage-gated potassium channel complex	IDA	11159685 27564677 28793216

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
voltage-gated potassium channel activity	IDA	11159685 27564677 28793216
voltage-gated potassium channel activity	IBA
protein binding	IPI	27564677
calmodulin binding	IDA	27564677
voltage-gated monoatomic cation channel activity	IDA	28793216

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity

voltage-gated potassium channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

binding [inference]

protein binding

calmodulin binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:14264	benign neonatal seizures	Alliance of Genome Resources

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026