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Guidelines

MIRAGE

peptidylglycine alpha-amidating monooxygenase L homeolog

Summary

Gene Symbol

pam.L

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

379207

PubChem

379207

Alliance of Genome Resources

Xenbase:XB-GENE-950939

Annotation

Keyword

Alternative splicing
Calcium
Copper
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Lyase
Metal-binding
Monooxygenase
Multifunctional enzyme
Reference proteome
Repeat
Signal
Transmembrane helix
Zinc

Proteins

Displaying **all 5** entries
UniProt	Protein Name
P08478	Peptide C-terminal alpha-amidating enzyme I Peptidyl-glycine alpha-amidating monooxygenase I
A0A1L8I1N2
A0A974E434
A0A974I5N1
A0A1L8I1N5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
peptide metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

organic substance metabolic process [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region
membrane	IEA
transport vesicle membrane	IEA
cytoplasmic vesicle	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
monooxygenase activity	IEA
peptidylglycine monooxygenase activity	IEA
peptidylamidoglycolate lyase activity	IEA
copper ion binding	IEA
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

peptidylglycine monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

peptidylglycine monooxygenase activity

carbon-nitrogen lyase activity [inference]

amidine-lyase activity [inference]

peptidylamidoglycolate lyase activity

catalytic activity, acting on a protein [inference]

peptidylamidoglycolate lyase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

copper ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidyl-glycine alpha-amidating monooxygenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
catalytic activity
copper ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
peptide metabolic process
peptidylglycine monooxygenase activity

Displaying **all 8** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
NHL repeat
PHM/PNGase F domain superfamily
Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
Six-bladed beta-propeller, TolB-like

Ortholog

Displaying **all 9** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5066	Xenbase:XB-GENE-950935
Xenopus tropicalis	18484	Xenbase:XB-GENE-950935
Xenopus tropicalis	25508	Xenbase:XB-GENE-950935
Xenopus tropicalis	36033	Xenbase:XB-GENE-950935
Homo sapiens	172108	HGNC:8596
Xenopus tropicalis	379207	Xenbase:XB-GENE-950935
Xenopus tropicalis	397736	Xenbase:XB-GENE-950935
Xenopus tropicalis	570822	Xenbase:XB-GENE-950935
Xenopus tropicalis	100170159	Xenbase:XB-GENE-950935

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025