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kinesin family member 2A

Summary

Gene Symbol

KIF2A

Organism

Homo sapiens (human)

External Links

NCBI Gene

3796

PubChem

3796

Alliance of Genome Resources

HGNC:6318

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Coiled coil
Cytoskeleton
Developmental protein
Differentiation
Disease variant
Lissencephaly
Microtubule
Mitosis
Motor protein
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A6Q8PFA6
B0AZS5
O00139	Kinesin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IGI	26323690
microtubule-based movement	IBA
microtubule depolymerization	TAS	26323690
mitotic spindle organization	IDA	18411309
nervous system development	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

spindle organization [inference]

mitotic spindle organization

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule polymerization or depolymerization [inference]

microtubule depolymerization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

mitotic spindle assembly

microtubule-based movement

cell cycle process [inference]

spindle organization [inference]

mitotic spindle organization

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

mitotic spindle assembly

cellular developmental process [inference]

cell differentiation

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

spindle organization [inference]

mitotic spindle organization

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule polymerization or depolymerization [inference]

microtubule depolymerization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

mitotic spindle assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

supramolecular fiber organization [inference]

microtubule depolymerization

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of cellular process [inference]

regulation of cell motility [inference]

regulation of cell migration

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
spindle pole	IDA	18411309
nucleoplasm	IDA
nucleolus	IDA
cytoplasm	IDA	26323690
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

kinesin complex

intracellular protein-containing complex [inference]

centriolar subdistal appendage

cellular anatomical entity [inference]

microtubule organizing center [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

spindle microtubule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoskeletal motor activity	TAS	9177777
microtubule motor activity	IBA
protein binding	IPI	18411309 25416956 26496610 26638075 31515488 32296183 32814053 35271311
ATP binding	IEA
microtubule binding	IDA	26323690

GO Hierarchy

molecular function

cytoskeletal motor activity

microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinesin-like protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
cytoskeletal motor activity
microtubule binding
microtubule-based movement
nucleotide binding

Displaying **all 5** entries
InterPro
Kinesin motor domain superfamily
Kinesin motor domain, conserved site
Kinesin motor domain
Kinesin-like protein
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090134	complex cortical dysplasia with other brain malformations 3	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3796	Xenbase:XB-GENE-951755
Drosophila melanogaster	11004	FB:FBgn0034824
Mus musculus	16563	Xenbase:XB-GENE-951755	MOUSE11174
Drosophila melanogaster	73470	FB:FBgn0030268
Rattus norvegicus	84391		RATNO22764
Macaca mulatta	696561		MACMU38830
Bos taurus	768014		BOVIN15886
Monodelphis domestica	100032333		MONDO18028
Equus caballus	100050982		HORSE20066
Ornithorhynchus anatinus	100074686		ORNAN11174

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Acknowledgements