acyl-CoA dehydrogenase very long chain

Summary
Gene Symbol
  • ACADVL
Aliases
  • ACAD6
  • LCACD
  • VLCAD
Organism
Homo sapiens (human)
External Links
NCBI Gene
37
HGNC
92
KEGG Gene ID
hsa:37
PubChem
37
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cardiomyopathy
  • Direct protein sequencing
  • Disease variant
  • FAD
  • Fatty acid metabolism
  • Mitochondrion inner membrane
  • Oxidoreductase
  • Phosphoprotein
  • Reference proteome
  • S-nitrosylation
  • Transit peptide
Proteins
Displaying all 2 entries
UniProt Protein Name
P49748
B3KPA6
Gene Ontology (GO)
GO Hierarchy
Displaying entries 6 - 7 of 7 in total
GO Term Evidence Code PMID
protein binding
identical protein binding
GO Hierarchy
Human Protein Atlas
ENSG00000072778

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K09479
Name
very long chain acyl-CoA dehydrogenase [EC:1.3.8.9]
References
Disease
Disease Ontology
Displaying entries 11 - 20 of 112 in total
DO ID Disease Name Source
DOID:0060676 catecholaminergic polymorphic ventricular tachycardia 2
DOID:0060677 catecholaminergic polymorphic ventricular tachycardia 3
DOID:0060678 catecholaminergic polymorphic ventricular tachycardia 4
DOID:0060679 catecholaminergic polymorphic ventricular tachycardia 5
DOID:0080155 very long chain acyl-CoA dehydrogenase deficiency
DOID:0080208 metabolic dysfunction-associated steatotic liver disease
DOID:0080326 familial hypertrophic cardiomyopathy
DOID:0080348 Alzheimer's disease 1
DOID:0110035 Alzheimer's disease 2
DOID:0110037 Alzheimer's disease 5
The Human Phenotype Ontology
Displaying entries 21 - 30 of 62 in total
HPO ID HPO Term
HP:0001649 Tachycardia
HP:0001655 Patent foramen ovale
HP:0001657 Prolonged QT interval
HP:0001663 Ventricular fibrillation
HP:0001678 Atrioventricular block
HP:0001698 Pericardial effusion
HP:0001942 Metabolic acidosis
HP:0001958 Nonketotic hypoglycemia
HP:0001985 Hypoketotic hypoglycemia
HP:0001987 Hyperammonemia
Displaying all 2 entries
Disease ID Disease Name
ORPHA:26793
  • very long chain acyl-CoA dehydrogenase deficiency
OMIM:201475
  • very long chain acyl-CoA dehydrogenase deficiency
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP000377
Gene Name
acyl-CoA dehydrogenase, very long chain

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024