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karyopherin subunit beta 1

Summary

Gene Symbol

KPNB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3837

PubChem

3837

Alliance of Genome Resources

HGNC:6400

Annotation

Keyword

3D-structure
ADP-ribosylation
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7Z752
Q14974	Importin-90 Karyopherin subunit beta-1 Nuclear factor p97 Pore targeting complex 97 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
RNA import into nucleus	IDA	9670026
protein import into nucleus	ISS
protein import into nucleus	IDA	15964792 20818336 7615630
protein import into nucleus	IMP	17209048
protein import into nucleus	IBA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

astral microtubule organization

spindle assembly [inference]

mitotic spindle assembly

cytoplasmic microtubule organization [inference]

astral microtubule organization

establishment of spindle localization [inference]

establishment of mitotic spindle localization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

establishment of mitotic spindle localization

microtubule-based movement [inference]

chromosome movement towards spindle pole [inference]

mitotic chromosome movement towards spindle pole

cell cycle process [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

astral microtubule organization

spindle assembly [inference]

mitotic spindle assembly

chromosome movement towards spindle pole [inference]

mitotic chromosome movement towards spindle pole

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

establishment of mitotic spindle localization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

RNA import into nucleus

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

astral microtubule organization

spindle assembly [inference]

mitotic spindle assembly

cytoplasmic microtubule organization [inference]

astral microtubule organization

establishment of spindle localization [inference]

establishment of mitotic spindle localization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

establishment of mitotic spindle localization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

supramolecular fiber organization [inference]

cytoplasmic microtubule organization [inference]

astral microtubule organization

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

RNA import into nucleus

protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA import into nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

RNA import into nucleus

protein import into nucleus

establishment of spindle localization [inference]

establishment of mitotic spindle localization

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

organelle localization [inference]

chromosome localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

chromosome movement towards spindle pole [inference]

mitotic chromosome movement towards spindle pole

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

RNA import into nucleus

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of small molecule metabolic process [inference]

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
nucleus	IBA
nuclear envelope	IDA	22701565
nuclear pore	TAS	7627554
nucleoplasm	NAS	20818336 7627554 7892216

GO Hierarchy

cellular component

protein-containing complex [inference]

nucleocytoplasmic transport complex [inference]

NLS-dependent protein nuclear import complex

nuclear protein-containing complex [inference]

nuclear pore

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

nuclear membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

ficolin-1-rich granule lumen

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle subcompartment [inference]

endoplasmic reticulum subcompartment [inference]

endoplasmic reticulum tubular network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22681889
protein binding	IPI	10353244 10523667 11024021 11311162 11971900 12372823 15282309 15494309 15507604 15870280 16314522 17209048 17596301 19668212 19680228 20701745 20818336 21072240 21858095 22084111 22500989 24169621 26195665 26496610 28514442 29734393 30833792 33961781 35044719 35271311 9405152
nuclear localization sequence binding	IBA
zinc ion binding	TAS	7615630
enzyme binding	IPI	22701565

GO Hierarchy

GTPase binding [inference]

small GTPase binding

protein domain specific binding

heat shock protein binding [inference]

Hsp90 protein binding

importin-alpha family protein binding

amide binding [inference]

peptide binding [inference]

signal sequence binding [inference]

nuclear localization sequence binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular carrier activity [inference]

nucleocytoplasmic carrier activity [inference]

nuclear import signal receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Importin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
nuclear import signal receptor activity
nuclear localization sequence binding
protein import into nucleus

Displaying **all 5** entries
InterPro
Armadillo-like helical
Armadillo-type fold
HEAT, type 2
Importin beta family
Importin-beta, N-terminal domain

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3837	Xenbase:XB-GENE-994068
Mus musculus	16211		MOUSE07576
Rattus norvegicus	24917		RATNO01922
Pan troglodytes	455176		PANTR13611
Canis lupus familiaris	491042		CANLF18823
Bos taurus	507804		BOVIN13146
Danio rerio	570700		DANRE15187
Macaca mulatta	694121		MACMU13900
Monodelphis domestica	100017474		MONDO14256
Equus caballus	100069121		HORSE03192

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements