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Repository for lectin-assisted multimodality data
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MIRAGE
KRAS proto-oncogene, GTPase
Summary
- Gene Symbol
-
- KRAS
- Aliases
-
- K-Ras4B
- KRAS1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Cardiomyopathy
- Cell membrane
- Cytoplasm
- Deafness
- Direct protein sequencing
- Disease variant
- Ectodermal dysplasia
- GTP-binding
- Glycoprotein
- Hydrolase
- Intellectual disability
- Isopeptide bond
- Membrane
- Methylation
- Palmitate
- Prenylation
- Proto-oncogene
- Reference proteome
- Transferase
- Ubl conjugation
- Ubl conjugation pathway
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| MAPK cascade | ||
| positive regulation of protein phosphorylation |
|
|
| Ras protein signal transduction | ||
| visual learning | ||
| gene expression |
GO Hierarchy
biological process
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi membrane | ||
| cytoplasm | ||
| mitochondrial outer membrane | ||
| endoplasmic reticulum membrane | ||
| cytosol |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| GTPase activity | ||
| GTPase activity | ||
| GTPase activity | ||
| G protein activity | ||
| protein binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Ras
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| GDP binding |
| GTP binding |
| InterPro |
|---|
| P-loop containing nucleoside triphosphate hydrolase |
| Small GTP-binding protein domain |
| Small GTPase, Ras-type |
| Small GTPase |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060233 | cardiofaciocutaneous syndrome | |
| DOID:0060581 | Noonan syndrome 3 | |
| DOID:0060688 | arteriovenous malformations of the brain | |
| DOID:0080365 | endometrial hyperplasia | |
| DOID:0110117 | autoimmune lymphoproliferative syndrome type 4 | |
| DOID:0111461 | cardiofaciocutaneous syndrome 2 | |
| DOID:0111530 | linear nevus sebaceous syndrome | |
| DOID:0111705 | oculoectodermal syndrome | |
| DOID:10534 | stomach cancer | |
| DOID:1059 | intellectual disability |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000014 | Abnormality of the bladder |
| HP:0000028 | Cryptorchidism |
| HP:0000036 | Abnormal penis morphology |
| HP:0000039 | Epispadias |
| HP:0000044 | Hypogonadotropic hypogonadism |
| HP:0000047 | Hypospadias |
| HP:0000069 | Abnormality of the ureter |
| HP:0000078 | Abnormality of the genital system |
| HP:0000085 | Horseshoe kidney |
| Disease ID | Disease Name |
|---|---|
| ORPHA:2396 |
|
| OMIM:109800 |
|
| ORPHA:3339 |
|
| OMIM:260350 |
|
| OMIM:211980 |
|
| OMIM:114480 |
|
| ORPHA:648 |
|
| ORPHA:1333 |
|
| ORPHA:144 |
|
| ORPHA:2612 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
-
- OMIM Phenotypes
-
- KEGG Diseases
-
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3265 | FB:FBgn0003205 | ||
| 3845 | Xenbase:XB-GENE-22063560 | ||
| 4893 | FB:FBgn0003205 | ||
| 16653 | Xenbase:XB-GENE-22063560 | MOUSE48355 | |
| 403871 | CANLF10970 | ||
| 473387 | PANTR06268 | ||
| 541140 | BOVIN30074 | ||
| 554186 | MONDO34878 | ||
| 707977 | MACMU03745 | ||
| 751104 | FELCA15885 |
