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Repository for lectin-assisted multimodality data
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MIRAGE
insulin receptor substrate 2
Summary
- Gene Symbol
-
- Irs2
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- Cytoplasm
- Direct protein sequencing
- Methylation
- Phosphoprotein
- Reference proteome
- Transducer
- Proteins
| UniProt | Protein Name |
|---|---|
| P81122 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of mesenchymal cell proliferation | ||
| negative regulation of B cell apoptotic process | ||
| brain development | ||
| cell population proliferation | ||
| cell population proliferation |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| transmembrane receptor protein tyrosine kinase adaptor activity | ||
| insulin receptor binding | ||
| insulin receptor binding | ||
| insulin receptor binding | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- insulin receptor substrate 2
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| insulin receptor binding |
| insulin receptor signaling pathway |
| phosphatidylinositol 3-kinase binding |
| InterPro |
|---|
| IRS-type PTB domain |
| Insulin receptor substrate |
| PH-like domain superfamily |
| Pleckstrin homology domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:9352 | type 2 diabetes mellitus |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3667 | FB:FBgn0024248 | ||
| 8471 | FB:FBgn0024248 | ||
| 8660 | ZFIN:ZDB-GENE-081104-462 | HUMAN17620 | |
| 16367 | FB:FBgn0024248 | ||
| 25467 | FB:FBgn0024248 | ||
| 29376 | RATNO11147 | ||
| 384783 | ZFIN:ZDB-GENE-081104-462 | ||
| 452657 | PANTR08073 | ||
| 572001 | DANRE44329 | ||
| 698536 | MACMU16286 |
