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keratin 1

Summary

Gene Symbol

KRT1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3848

PubChem

3848

Alliance of Genome Resources

HGNC:6412

Annotation

Keyword

3D-structure
Cell membrane
Citrullination
Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Ichthyosis
Intermediate filament
Keratin
Methylation
Palmoplantar keratoderma
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P04264	67 kDa cytokeratin Cytokeratin-1 Hair alpha protein Keratin-1 Type-II keratin Kb1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
complement activation, lectin pathway	IPI	11549596
intermediate filament organization	IBA
establishment of skin barrier	IEA
keratinization	IBA
protein heterotetramerization	IDA	27595935

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, lectin pathway

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, lectin pathway

innate immune response [inference]

complement activation, lectin pathway

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

cellular process [inference]

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization [inference]

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization [inference]

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

supramolecular fiber organization [inference]

intermediate filament organization

multicellular organismal process [inference]

keratinization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development [inference]

skin epidermis development [inference]

establishment of skin barrier

epithelium development [inference]

skin epidermis development [inference]

establishment of skin barrier

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, lectin pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, lectin pathway

response to oxidative stress

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, lectin pathway

innate immune response [inference]

complement activation, lectin pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, lectin pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, lectin pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of inflammatory response [inference]

negative regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	HDA	21630459
blood microparticle	HDA	22516433
cytoplasm	IDA	32179842
extracellular space	HDA	22664934 23580065
extracellular region	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane [inference]

cornified envelope

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament [inference]

keratin filament

Displaying **all 5** entries
GO Term	Evidence Code	PMID
structural constituent of skin epidermis	IBA IDA	7543090
signaling receptor activity	NAS	11290596
protein heterodimerization activity	IDA	27595935
carbohydrate binding	IPI	11549596
protein binding	IPI	11290596 16923132 20562859 24940650 25910212 27595935 32296183 39009827

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of skin epidermis

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

carbohydrate binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0070550	KRT1-related nonepidermolytic palmoplantar keratoderma	Alliance of Genome Resources
DOID:0070551	epidermolytic palmoplantar keratoderma 2	Alliance of Genome Resources
DOID:0081110	keratosis palmoplantaris striata 3	Alliance of Genome Resources
DOID:0081358	epidermolytic hyperkeratosis 1	Alliance of Genome Resources
DOID:4603	epidermolytic hyperkeratosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3848	Xenbase:XB-GENE-876590
Xenopus tropicalis	3849	Xenbase:XB-GENE-876590
Xenopus tropicalis	3852	Xenbase:XB-GENE-6035591
Danio rerio	3855	ZFIN:ZDB-GENE-991110-23
Danio rerio	3856	ZFIN:ZDB-GENE-991110-23
Caenorhabditis elegans	3858	WB:WBGene00002056
Xenopus tropicalis	9119	Xenbase:XB-GENE-6035591
Caenorhabditis elegans	13346	WB:WBGene00002055
Caenorhabditis elegans	14580	WB:WBGene00002055
Mus musculus	16678	Xenbase:XB-GENE-6035591	MOUSE16746