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keratin 5

Summary

Gene Symbol

KRT5

Organism

Homo sapiens (human)

External Links

NCBI Gene

3852

PubChem

3852

Alliance of Genome Resources

HGNC:6442

Annotation

Keyword

3D-structure
Coiled coil
Cytoplasm
Disease variant
Epidermolysis bullosa
Intermediate filament
Keratin
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P13647	58 kDa cytokeratin Cytokeratin-5 Keratin-5 Type-II keratin Kb5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
epidermis development	TAS	7520042
response to mechanical stimulus	ISS
regulation of cell migration	ISS
keratinization	IBA
regulation of protein localization	ISS

GO Hierarchy

biological process

cellular process [inference]

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

intermediate filament polymerization

protein-containing complex organization [inference]

intermediate filament polymerization or depolymerization [inference]

intermediate filament polymerization

protein-containing complex assembly [inference]

protein polymerization [inference]

intermediate filament polymerization

supramolecular fiber organization [inference]

intermediate filament organization

multicellular organismal process [inference]

keratinization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of cellular process [inference]

regulation of cellular localization [inference]

regulation of protein localization

regulation of cell motility [inference]

regulation of cell migration

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	HDA	21630459
cytoplasm	ISS
cytoplasm	IDA	20128788 22170488
cytosol	TAS
intermediate filament	IDA	10852826

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

keratin filament

Displaying **all 4** entries
GO Term	Evidence Code	PMID
structural constituent of cytoskeleton	TAS	7520042
protein binding	IPI	10727209 10852826 15671067 15731013 22705788 24940650 25416956 31995743 32296183 37671092
structural constituent of skin epidermis	IBA
scaffold protein binding	IPI	10852826

GO Hierarchy

molecular function

structural molecule activity [inference]

binding [inference]

protein binding

scaffold protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Keratin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
intermediate filament organization

Displaying 1 entry
InterPro
Intermediate filament, rod domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060256	Dowling-Degos disease	Alliance of Genome Resources
DOID:0111346	epidermolysis bullosa simplex with mottled pigmentation	Alliance of Genome Resources
DOID:4644	epidermolysis bullosa simplex	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 62 in total

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Species	Gene ID	Orthologous MAtrix
Rhinopithecus roxellana	104670633	RHIRO08911
Rhinopithecus roxellana	104670634	RHIRO08911
Pteropus vampyrus	105302688	PTEVA03369
Mandrillus leucophaeus	105555196	MANLE15589
Aotus nancymaae	105715833	AOTNA25200
Propithecus coquereli	105815486	PROCO09328
Microcebus murinus	105870459	MICMU13026
Dipodomys ordii	105997891	DIPOR20781
Rhinopithecus bieti	108521556	RHIBE20660
Phascolarctos cinereus	110194102	PHACI28215

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Annotation

OrthoDB (Group)

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Acknowledgements