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Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

38657

PubChem

38657

Alliance of Genome Resources

FB:FBgn0003984

Annotation

Keyword

Alternative splicing
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Immunoglobulin domain
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q94918	Epidermal growth factor-like protein Protein defective dorsal discs
Q59E20

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
epidermal growth factor receptor signaling pathway	IDA	10349622 9531530
epidermal growth factor receptor signaling pathway	IMP	11141565 15238521 8824589 9806926
epidermal growth factor receptor signaling pathway	IGI	22595244 8824589
brain development	IMP	12646129
peripheral nervous system development	IMP	12967983

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway

epidermal growth factor receptor signaling pathway

intracellular signal transduction

cellular developmental process [inference]

cell fate specification [inference]

cell fate specification involved in pattern specification [inference]

notum cell fate specification

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

compound eye photoreceptor cell differentiation [inference]

R8 cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly

cell projection organization [inference]

cell projection assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

olfactory learning

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

proximal/distal pattern formation, imaginal disc [inference]

leg disc proximal/distal pattern formation

leg disc pattern formation [inference]

leg disc proximal/distal pattern formation

proximal/distal pattern formation [inference]

proximal/distal pattern formation, imaginal disc [inference]

leg disc proximal/distal pattern formation

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

olfactory learning

chemosensory behavior [inference]

olfactory behavior [inference]

olfactory learning

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

imaginal disc-derived wing vein morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

anatomical structure development [inference]

notum development

tube development [inference]

digestive tract development [inference]

midgut development

animal organ development

brain development

system development [inference]

peripheral nervous system development

respiratory system development [inference]

open tracheal system development

appendage development [inference]

imaginal disc-derived appendage development [inference]

haltere development

cellular developmental process [inference]

cell fate specification [inference]

cell fate specification involved in pattern specification [inference]

notum cell fate specification

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

compound eye photoreceptor cell differentiation [inference]

R8 cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

regulation of border follicle cell migration [inference]

positive regulation of border follicle cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of reproductive process [inference]

positive regulation of border follicle cell migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of stem cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway

epidermal growth factor receptor signaling pathway

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation [inference]

regulation of stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

regulation of border follicle cell migration [inference]

positive regulation of border follicle cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of border follicle cell migration

regulation of border follicle cell migration [inference]

positive regulation of border follicle cell migration

regulation of reproductive process [inference]

regulation of border follicle cell migration [inference]

positive regulation of border follicle cell migration

positive regulation of reproductive process [inference]

positive regulation of border follicle cell migration

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	NAS	8824589
extracellular space	IDA	8824589
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	IBA
epidermal growth factor receptor binding	IDA	9531530
epidermal growth factor receptor binding	IMP	8824589
growth factor activity
heparin binding	IDA	22595244

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

receptor ligand activity

growth factor activity

growth factor receptor binding [inference]

epidermal growth factor receptor binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Roundabout

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 5** entries
InterPro
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:8824589

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	3084	Xenbase:XB-GENE-1011451
Danio rerio	9542	ZFIN:ZDB-GENE-070615-10
Xenopus tropicalis	10718	Xenbase:XB-GENE-984146
Xenopus tropicalis	38657	Xenbase:XB-GENE-1011451
Xenopus tropicalis	373595	Xenbase:XB-GENE-1011451
Danio rerio	432361	ZFIN:ZDB-GENE-090205-2

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements