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platelet-derived growth factor receptor, alpha polypeptide

Summary

Gene Symbol

pdgfra

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

386856

PubChem

386856

Alliance of Genome Resources

ZFIN:ZDB-GENE-990415-208

Annotation

Keyword

ATP-binding
Cell membrane
Cell projection
Chemotaxis
Developmental protein
Disulfide bond
Glycoprotein
Golgi apparatus
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Repeat
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9DE49	Alpha platelet-derived growth factor receptor Alpha-type platelet-derived growth factor receptor

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
chemotaxis	IEA
cerebellum vasculature development	IGI	25250569
embryonic cranial skeleton morphogenesis	IBA IMP	23861062
heart development	IMP	28167492
roof of mouth development	IMP	18264099 23861062

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

cardioblast cell midline fusion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

platelet-derived growth factor receptor signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cell migration involved in heart development [inference]

cell migration to the midline involved in heart development [inference]

cardioblast migration to the midline involved in heart field formation [inference]

cardiac muscle progenitor cell migration to the midline involved in heart field formation

cell migration involved in heart formation [inference]

cardioblast migration [inference]

cardioblast migration to the midline involved in heart field formation [inference]

cardiac muscle progenitor cell migration to the midline involved in heart field formation

multicellular organismal process [inference]

multicellular organism development

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis [inference]

embryonic cranial skeleton morphogenesis

skeletal system morphogenesis [inference]

embryonic skeletal system morphogenesis [inference]

embryonic cranial skeleton morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis [inference]

embryonic cranial skeleton morphogenesis

embryonic neurocranium morphogenesis

anatomical structure development [inference]

multicellular organism development

animal organ development [inference]

heart development

system development [inference]

vasculature development [inference]

cerebellum vasculature development

roof of mouth development

locomotion [inference]

taxis [inference]

chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

platelet-derived growth factor receptor signaling pathway

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation

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GO Term	Evidence Code	PMID
membrane	IEA
Golgi apparatus	IEA ISS
receptor complex	IBA
plasma membrane	IBA IEA
cell projection	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

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GO Term	Evidence Code	PMID
kinase activity	IEA
platelet-derived growth factor alpha-receptor activity	IBA IEA
platelet-derived growth factor binding	IBA
transmembrane receptor protein tyrosine kinase activity	IEA
protein tyrosine kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

platelet-derived growth factor binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 26 in total

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DO ID	Disease Name	Source
DOID:0050902	medulloblastoma	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:12215	oligohydramnios	Alliance of Genome Resources
DOID:1240	leukemia	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2526	prostate adenocarcinoma	Alliance of Genome Resources
DOID:2696	Leydig cell tumor	Alliance of Genome Resources
DOID:305	carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5156	HGNC:8803	HUMAN75588
Mus musculus	18595	MGI:97530	MOUSE44102
Rattus norvegicus	25267	RGD:3284	RATNO08104
Drosophila melanogaster	34127	FB:FBgn0032006
Caenorhabditis elegans	175182	WB:WBGene00006894
Bos taurus	282301		BOVIN31497
Canis lupus familiaris	442860		CANLF03395
Pan troglodytes	461318		PANTR33962
Macaca mulatta	697002		MACMU36309
Macaca mulatta	697725		MACMU36309