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TraB domain containing 2B

Summary

Gene Symbol

TRABD2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

388630

PubChem

388630

Alliance of Genome Resources

HGNC:44200

Annotation

Keyword

Cell membrane
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Signal
Transmembrane helix
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
A6NFA1	Heart, kidney and adipose-enriched transmembrane protein homolog TRAB domain-containing protein 2B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	22726442
Wnt signaling pathway	IEA
negative regulation of Wnt signaling pathway	IDA	22726442
negative regulation of Wnt signaling pathway	IBA
positive regulation of protein-containing complex assembly	IDA	22726442

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

regulation of protein oxidation [inference]

positive regulation of protein oxidation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

regulation of protein oxidation [inference]

positive regulation of protein oxidation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

regulation of protein oxidation [inference]

positive regulation of protein oxidation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein oxidation

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA
plasma membrane	IDA	22726442
plasma membrane	IBA
organelle membrane	IDA	22726442
organelle membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	IDA	22726442
metalloendopeptidase activity	IBA
protein binding	IPI	22726442
Wnt-protein binding	IDA	22726442
Wnt-protein binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

Wnt-protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metalloprotease TIKI2

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
Wnt-protein binding
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 2** entries
InterPro
Protease TIKI1/2-like
TraB/PrgY/GumN family

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	129293	WB:WBGene00007351
Xenopus tropicalis	181571	Xenbase:XB-GENE-6050974
Xenopus tropicalis	388630	Xenbase:XB-GENE-6050974
Caenorhabditis elegans	564021	WB:WBGene00007351
Xenopus tropicalis	566028	Xenbase:XB-GENE-6050974
Mus musculus	666048	Xenbase:XB-GENE-6050974	MOUSE40507
Rattus norvegicus	689914		RATNO34054
Macaca mulatta	712301		MACMU24454
Pan troglodytes	740742		PANTR21026
Equus caballus	100063464		HORSE27581