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Transient receptor potential cation channel A1

Summary

Gene Symbol

TrpA1

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

39015

PubChem

39015

Alliance of Genome Resources

FB:FBgn0035934

Annotation

Keyword

3D-structure
ANK repeat
Alternative splicing
Cell membrane
Glycoprotein
Ion channel
Receptor
Reference proteome
Repeat
Sensory transduction
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
M9PBX8
Q7Z020	Ankyrin-like with transmembrane domains protein 1
H0USS9
H0UST1
G8IQ59

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
detection of chemical stimulus involved in sensory perception of bitter taste	IMP	20404155
monoatomic ion transport	IEA
ion transport	IEA
monoatomic cation transport	IDA	12815418 23027824
calcium ion transport	IDA	18548007

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular response to fluid shear stress [inference]

cellular response to pulsatile fluid shear stress

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

multicellular organismal process [inference]

behavior [inference]

locomotion [inference]

taxis [inference]

energy taxis [inference]

phototaxis [inference]

negative phototaxis

negative energy taxis [inference]

negative phototaxis

thermotaxis

response to stimulus [inference]

response to stress [inference]

response to heat

cellular response to heat

cellular response to stress [inference]

cellular response to heat

cellular response to fluid shear stress [inference]

cellular response to pulsatile fluid shear stress

response to fluid shear stress [inference]

cellular response to fluid shear stress [inference]

cellular response to pulsatile fluid shear stress

response to pulsatile fluid shear stress [inference]

cellular response to pulsatile fluid shear stress

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of hot stimulus involved in thermoception

detection of temperature stimulus involved in sensory perception of pain

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

cellular response to heat

temperature compensation of the circadian clock

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of hot stimulus involved in thermoception

detection of temperature stimulus involved in sensory perception of pain

response to radiation [inference]

response to light stimulus

detection of light stimulus [inference]

phototransduction

phototaxis [inference]

negative phototaxis

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of hot stimulus involved in thermoception

detection of temperature stimulus involved in sensory perception of pain

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of hot stimulus involved in thermoception

detection of temperature stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of hot stimulus involved in thermoception

detection of temperature stimulus involved in sensory perception of pain

detection of chemical stimulus [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste [inference]

detection of chemical stimulus involved in sensory perception of bitter taste

detection of chemical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste [inference]

detection of chemical stimulus involved in sensory perception of bitter taste

detection of chemical stimulus involved in sensory perception of pain

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in thermoception

detection of hot stimulus involved in thermoception

detection of temperature stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular response to fluid shear stress [inference]

cellular response to pulsatile fluid shear stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport

metal ion transport [inference]

calcium ion transport

monoatomic cation transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of circadian rhythm [inference]

temperature compensation of the circadian clock

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of calcium-mediated signaling

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA	37015924 37224252
membrane	IC	12815418
membrane	IEA
cation channel complex	IDA	23027824

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
ion channel activity	IEA
monoatomic ion channel activity	IEA
monoatomic cation channel activity	IDA	12815418
calcium channel activity	IDA	18548007 37224252
ligand-gated monoatomic ion channel activity	IDA	20237474

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

ligand-gated monoatomic ion channel activity

temperature-gated ion channel activity [inference]

temperature-gated cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

ligand-gated monoatomic ion channel activity

temperature-gated ion channel activity [inference]

temperature-gated cation channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity

temperature-gated ion channel activity [inference]

temperature-gated cation channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

taste receptor activity [inference]

bitter taste receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transient receptor potential cation channel

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 3** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Ion transport domain

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
plasma membrane	PMID:37015924 PMID:37224252
cation channel complex	PMID:23027824

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	8989	Xenbase:XB-GENE-1004945
Xenopus tropicalis	39015	Xenbase:XB-GENE-1004945
Xenopus tropicalis	178118	Xenbase:XB-GENE-1004945
Xenopus tropicalis	277328	Xenbase:XB-GENE-1004945
Xenopus tropicalis	312896	Xenbase:XB-GENE-1004945