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Gram-negative bacteria binding protein 3

Summary

Gene Symbol

GNBP3

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

39020

PubChem

39020

Alliance of Genome Resources

FB:FBgn0040321

Annotation

Keyword

3D-structure
Glycoprotein
Innate immunity
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NHA8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
detection of molecule of fungal origin	IDA	19692333
regulation of innate immune response	ISS
antifungal humoral response	IMP	30735676
Toll receptor ligand protein activation cascade	IGI IMP	18724373 19590012 38175756
positive regulation of melanization defense response	IMP	30735676

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antifungal humoral response

innate immune response [inference]

antifungal innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

Toll receptor ligand protein activation cascade

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

Toll receptor ligand protein activation cascade

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

Toll receptor ligand protein activation cascade

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

Toll receptor ligand protein activation cascade

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to fungus [inference]

defense response to fungus [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antifungal humoral response

innate immune response [inference]

antifungal innate immune response

defense response to fungus [inference]

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antifungal humoral response

innate immune response [inference]

antifungal innate immune response

defense response to fungus [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antifungal humoral response

innate immune response [inference]

antifungal innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of fungal origin [inference]

detection of molecule of fungal origin

response to other organism [inference]

response to fungus [inference]

defense response to fungus [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antifungal humoral response

innate immune response [inference]

antifungal innate immune response

defense response to fungus [inference]

detection of external biotic stimulus [inference]

detection of molecule of fungal origin

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of fungal origin

response to external biotic stimulus [inference]

response to molecule of fungal origin [inference]

detection of molecule of fungal origin

response to other organism [inference]

response to fungus [inference]

defense response to fungus [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

antifungal humoral response

innate immune response [inference]

antifungal innate immune response

defense response to fungus [inference]

detection of external biotic stimulus [inference]

detection of molecule of fungal origin

response to chemical [inference]

response to organic substance [inference]

response to molecule of fungal origin [inference]

detection of molecule of fungal origin

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of molecule of fungal origin

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of fungal origin

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

regulation of innate immune response

regulation of melanization defense response [inference]

positive regulation of melanization defense response

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of melanization defense response

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of melanization defense response

regulation of melanization defense response [inference]

positive regulation of melanization defense response

regulation of secondary metabolic process [inference]

regulation of melanization defense response [inference]

positive regulation of melanization defense response

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of melanization defense response

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of melanization defense response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of innate immune response

regulation of melanization defense response [inference]

positive regulation of melanization defense response

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of innate immune response

regulation of melanization defense response [inference]

positive regulation of melanization defense response

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

regulation of innate immune response

regulation of melanization defense response [inference]

positive regulation of melanization defense response

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of innate immune response

regulation of melanization defense response [inference]

positive regulation of melanization defense response

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

positive regulation of melanization defense response

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway

pattern recognition receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of melanization defense response

regulation of melanization defense response [inference]

positive regulation of melanization defense response

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of melanization defense response

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	ISS
cell surface	IDA	19692333
extracellular space	IDA	38175756

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
hydrolase activity	IKR IMR	10827089
(1->3)-beta-D-glucan binding	IDA	16385003 19692333
(1->3)-beta-D-glucan immune receptor activity	IDA	38175756
beta-glucanase activity	IKR IMR	10827089
pattern recognition receptor activity	ISS	10827089

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

beta-glucanase activity

binding [inference]

lipid binding [inference]

lipopolysaccharide binding

carbohydrate binding

polysaccharide binding [inference]

(1->3)-beta-D-glucan binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

pattern recognition receptor activity

polysaccharide immune receptor activity [inference]

(1->3)-beta-D-glucan immune receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Xyloglucan endotransglucosylase/hydrolase

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 2** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
Glycoside hydrolase family 16

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
cell surface	PMID:19692333
extracellular space	PMID:38175756
membrane	FB:FBrf0231198

Ortholog

Displaying entries **1 - 10** of 37 in total

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Species	Gene ID	OrthoDB
Drosophila pseudoobscura	4812469	7237_1:00327a
Drosophila ananassae	6506997	7217_1:001184
Drosophila yakuba	6532641	7245_1:0020a5
Drosophila erecta	6545475	7220_1:000de4
Drosophila grimshawi	6556534	7222_1:0024cc
Drosophila mojavensis	6581700	7230_1:00248c
Drosophila persimilis	6600583	7234_1:002b9d
Drosophila sechellia	6604957	7238_1:001868
Drosophila virilis	6623670	7244_1:0014e1
Drosophila willistoni	6639433	7260_0:0005e0

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements