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Peptidoglycan recognition protein LF

Summary

Gene Symbol

PGRP-LF

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

39064

PubChem

39064

Alliance of Genome Resources

FB:FBgn0035977

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Innate immunity
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8SXQ7	PGRP-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
determination of adult lifespan	IMP	22366109
peptidoglycan catabolic process	IKR	12496260
peptidoglycan catabolic process	IMR	12496260
response to bacterium	IDA	19237508
antibacterial humoral response	IMP	12777387

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan catabolic process

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

peptidoglycan catabolic process

multicellular organismal process [inference]

determination of adult lifespan

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism

antimicrobial humoral response [inference]

antibacterial humoral response

defense response to bacterium [inference]

antibacterial humoral response

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of defense response [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of defense response [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IDA	12777387 17967349

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
signaling receptor binding	IPI	21372849
zinc ion binding	IEA
N-acetylmuramoyl-L-alanine amidase activity	IMR	12496260
N-acetylmuramoyl-L-alanine amidase activity	IKR	12496260
peptidoglycan binding	IDA	21372849

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acetylmuramoyl-L-alanine amidase activity

peptidoglycan muralytic activity [inference]

N-acetylmuramoyl-L-alanine amidase activity

binding [inference]

protein binding [inference]

signaling receptor binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

peptidoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidoglycan recognition protein

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism

Displaying **all 3** entries
Gene Ontology
N-acetylmuramoyl-L-alanine amidase activity
peptidoglycan binding
zinc ion binding

Displaying **all 4** entries
InterPro
N-acetylmuramoyl-L-alanine amidase domain
N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
Peptidoglycan recognition protein family domain, metazoa/bacteria
Peptidoglycan recognition protein

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
plasma membrane	PMID:12777387 PMID:17967349

Ortholog

Displaying entries **1 - 10** of 14 in total

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	8993	Xenbase:XB-GENE-491319
Xenopus tropicalis	32099	Xenbase:XB-GENE-491319
Xenopus tropicalis	32534	Xenbase:XB-GENE-491319
Xenopus tropicalis	35859	Xenbase:XB-GENE-491319
Xenopus tropicalis	35862	Xenbase:XB-GENE-491319
Xenopus tropicalis	38858	Xenbase:XB-GENE-491319
Xenopus tropicalis	39064	Xenbase:XB-GENE-491319
Xenopus tropicalis	39869	Xenbase:XB-GENE-491319
Xenopus tropicalis	39870	Xenbase:XB-GENE-491319
Homo sapiens	57115	HGNC:30015

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OrthoDB (Group)

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Acknowledgements