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laminin subunit alpha 5

Summary

Gene Symbol

LAMA5

Organism

Homo sapiens (human)

External Links

NCBI Gene

3911

PubChem

3911

Alliance of Genome Resources

HGNC:6485

Annotation

Keyword

3D-structure
Alternative splicing
Basement membrane
Cell adhesion
Coiled coil
Disease variant
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O15230	Laminin-10 subunit alpha Laminin-11 subunit alpha Laminin-15 subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
branching involved in ureteric bud morphogenesis	IEA
morphogenesis of a polarized epithelium	IEA
hair follicle development	IEA
cell adhesion	IDA	15975931
integrin-mediated signaling pathway	IMP	11821406

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration [inference]

trunk neural crest cell migration

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

postsynapse organization

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

branching involved in salivary gland morphogenesis

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

branching involved in salivary gland morphogenesis

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

skeletal system morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

branching involved in salivary gland morphogenesis

anatomical structure development [inference]

hair follicle development

animal organ development [inference]

muscle structure development [inference]

muscle organ development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell adhesion

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation

regulation of cell motility [inference]

regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
basement membrane	NAS	11821406
basement membrane	IDA	14557481
laminin-5 complex	IEA
extracellular space	IDA	10964500

GO Hierarchy

cellular component

protein-containing complex [inference]

laminin complex [inference]

cellular anatomical entity [inference]

extracellular region

synaptic cleft

extracellular space

cell junction [inference]

synapse [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
integrin binding	IDA	11821406
extracellular matrix structural constituent	RCA	20551380 25037231 27068509 27559042 28675934
receptor ligand activity	IDA	15975931
cell adhesion mediator activity	IDA	15975931

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cell adhesion molecule binding [inference]

protein-containing complex binding [inference]

integrin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060993	bent bone dysplasia syndrome 2	Alliance of Genome Resources
DOID:2590	familial nephrotic syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 33 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3909	FB:FBgn0002526
Xenopus tropicalis	3911	Xenbase:XB-GENE-1007923
Drosophila melanogaster	16774	FB:FBgn0002526
Mus musculus	16776	Xenbase:XB-GENE-1007923	MOUSE31722
Xenopus tropicalis	38723	Xenbase:XB-GENE-1007923
Rattus norvegicus	140433	Xenbase:XB-GENE-1007923	RATNO28903
Xenopus tropicalis	177956	Xenbase:XB-GENE-1007923
Danio rerio	321243		DANRE24521
Monodelphis domestica	100026192		MONDO01915
Equus caballus	100058057		HORSE21003