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laminin subunit beta 2

Summary

Gene Symbol

LAMB2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3913

PubChem

3913

Alliance of Genome Resources

HGNC:6487

Annotation

Keyword

Basement membrane
Cell adhesion
Coiled coil
Disease variant
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P55268	Laminin B1s chain Laminin-11 subunit beta Laminin-14 subunit beta Laminin-15 subunit beta Laminin-3 subunit beta Laminin-4 subunit beta Laminin-7 subunit beta Laminin-9 subunit beta S-laminin subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cell adhesion	IEA
axon guidance	IEA
neuromuscular junction development	IEA
visual perception	IEA
astrocyte development	IEA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell growth [inference]

developmental cell growth [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development [inference]

metanephric podocyte development

metanephric glomerular epithelial cell development [inference]

metanephric podocyte development

glial cell development [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

extracellular structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development [inference]

metanephric glomerular basement membrane development

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development [inference]

metanephric glomerular basement membrane development

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

developmental process [inference]

anatomical structure development [inference]

glomerular basement membrane development [inference]

metanephric glomerular basement membrane development

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development [inference]

metanephric podocyte development

metanephric glomerular epithelial cell development [inference]

metanephric podocyte development

glial cell development [inference]

retina development in camera-type eye

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development [inference]

metanephric podocyte development

metanephric glomerular epithelial cell development [inference]

metanephric podocyte development

glial cell development [inference]

growth [inference]

cell growth [inference]

developmental cell growth [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

developmental growth [inference]

developmental cell growth [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

developmental growth involved in morphogenesis [inference]

sprouting of injured axon [inference]

axon extension involved in regeneration

neuron projection extension [inference]

axon extension [inference]

axon extension involved in regeneration

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of integrin-mediated signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation

positive regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of extracellular matrix organization [inference]

regulation of basement membrane organization

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
basement membrane	NAS	1678389
basement membrane	IDA	10964500 14557481 2099832
laminin-3 complex	IPI	10964500
endoplasmic reticulum lumen	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

laminin complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion

cellular anatomical entity [inference]

extracellular region

synaptic cleft

cell junction [inference]

synapse [inference]

neuromuscular junction

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
integrin binding	IEA
structural molecule activity	NAS	7698745
extracellular matrix structural constituent	RCA	20551380 25037231 27068509 27559042 28675934
extracellular matrix structural constituent	ISS
protein binding	IPI	32296183

GO Hierarchy

molecular function

structural molecule activity

extracellular matrix structural constituent

structural constituent of synapse-associated extracellular matrix

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

laminin

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
animal organ morphogenesis
substrate adhesion-dependent cell spreading
tissue development

Displaying **all 4** entries
InterPro
EGF-like domain
Laminin IV type B
Laminin, N-terminal
Laminin-type EGF domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060852	Pierson syndrome	Alliance of Genome Resources
DOID:0080380	nephrotic syndrome type 5	Alliance of Genome Resources
DOID:1070	primary open angle glaucoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	3912	WB:WBGene00002247
Xenopus tropicalis	3913	Xenbase:XB-GENE-5935962
Caenorhabditis elegans	3914	WB:WBGene00002247
Caenorhabditis elegans	16777	WB:WBGene00002247
Mus musculus	16779	Xenbase:XB-GENE-5935962	MOUSE62322
Caenorhabditis elegans	22798	WB:WBGene00002247
Rattus norvegicus	25473	Xenbase:XB-GENE-5935962	RATNO41227
Xenopus tropicalis	177292	Xenbase:XB-GENE-5935962
Danio rerio	337767		DANRE24165
Pan troglodytes	460365		PANTR31116