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Aldo-keto reductase 1B

Summary

Gene Symbol

Akr1B

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

39304

PubChem

39304

Alliance of Genome Resources

FB:FBgn0086254

Annotation

Keyword

Oxidoreductase
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q9VTK9
M9PF61
Q8IQF8
M9PI17

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
sorbitol biosynthetic process	IGI	35687590
glucuronate catabolic process to xylulose 5-phosphate	ISS
polyol biosynthetic process	IMP	31350199
fructose biosynthetic process	IGI	35687590

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process [inference]

sorbitol biosynthetic process

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process [inference]

sorbitol biosynthetic process

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process [inference]

sorbitol biosynthetic process

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carbohydrate derivative biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

hexitol metabolic process [inference]

sorbitol metabolic process [inference]

sorbitol biosynthetic process

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process

alditol biosynthetic process [inference]

hexitol biosynthetic process [inference]

sorbitol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

uronic acid metabolic process [inference]

glucuronate metabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate metabolic process [inference]

xylulose 5-phosphate metabolic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

organophosphate biosynthetic process [inference]

xylulose 5-phosphate biosynthetic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

glucuronate catabolic process [inference]

glucuronate catabolic process to xylulose 5-phosphate

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	IDA	31350199
nucleoplasm	HDA	25294944
mitochondrion	ISS
cytosol	IBA
cytosol	HDA	25294944

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
alditol:NADP+ 1-oxidoreductase activity	IDA	31350199
alditol:NADP+ 1-oxidoreductase activity	IBA
oxidoreductase activity	IEA
indanol dehydrogenase activity
L-glucuronate reductase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity [inference]

alcohol dehydrogenase (NADP+) activity [inference]

alditol:NADP+ 1-oxidoreductase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aldo-keto

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
alditol
oxidoreductase activity

Displaying **all 4** entries
InterPro
Aldo-keto reductase
Aldo/keto reductase, conserved site
NADP-dependent oxidoreductase domain superfamily
NADP-dependent oxidoreductase domain

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
cytosol	PMID:25294944
nucleus	FB:FBrf0161605
membrane	FB:FBrf0231198
extracellular space	PMID:31350199
nucleoplasm	PMID:25294944

Ortholog

Displaying entries **1 - 10** of 17 in total

1

2

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	231	Xenbase:XB-GENE-5821742
Caenorhabditis elegans	1109	WB:WBGene00012722
Caenorhabditis elegans	1645	WB:WBGene00012722
Caenorhabditis elegans	1646	WB:WBGene00012722
Homo sapiens	6718	HGNC:388
Caenorhabditis elegans	8644	WB:WBGene00012722
Xenopus tropicalis	10327	Xenbase:XB-GENE-1014353
Xenopus tropicalis	11677	Xenbase:XB-GENE-5821742
Xenopus tropicalis	24192	Xenbase:XB-GENE-5821742
Xenopus tropicalis	39304	Xenbase:XB-GENE-1014353

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Acknowledgements