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lipocalin 2

Summary

Gene Symbol

LCN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3934

PubChem

3934

Alliance of Genome Resources

HGNC:6526

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Innate immunity
Iron transport
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P80188	25 kDa alpha-2-microglobulin-related subunit of MMP-9 Lipocalin-2 Oncogene 24p3 Siderocalin p25

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
apoptotic process	IEA
siderophore transport	ISS
defense response to bacterium	IDA	27780864
innate immune response	ISS
positive regulation of cold-induced thermogenesis	ISS	20332347

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

iron coordination entity transport [inference]

siderophore transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	TAS
extracellular region	HDA	27068509
extracellular space	IDA	25645918 27780864
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
iron ion binding	ISS
iron ion binding	IDA	27780864
protein binding	IPI	32296183 33961781
identical protein binding	IPI	32296183
iron ion sequestering activity	IDA	27780864

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

ion binding [inference]

anion binding [inference]

enterobactin binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

macrolide binding [inference]

enterobactin binding

molecular sequestering activity [inference]

metal ion sequestering activity [inference]

iron ion sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

neutrophil gelatinase-associated

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
small molecule binding

Displaying **all 5** entries
InterPro
Calycin
Lipocalin family conserved site
Lipocalin/cytosolic fatty-acid binding domain
Lipocalin
Neutrophil gelatinase-associated lipocalin/epididymal-specific lipocalin-12

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080784	urinary tract infection	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	3934	RGD:69408
Mus musculus	16819	RGD:69408	MOUSE34232
Rattus norvegicus	170496	RGD:69408	RATNO28323
Pan troglodytes	464764		PANTR44922
Canis lupus familiaris	491320		CANLF19409
Bos taurus	526639		BOVIN03212
Sus scrofa	100153501		PIGXX16250
Oryctolagus cuniculus	100352980		RABIT17028
Pongo abelii	100444138		PONAB36204
Nomascus leucogenys	100599124		NOMLE36503

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements