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lipocalin 2

Summary

Gene Symbol

LCN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3934

PubChem

3934

Alliance of Genome Resources

HGNC:6526

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Innate immunity
Iron transport
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P80188	25 kDa alpha-2-microglobulin-related subunit of MMP-9 Lipocalin-2 Oncogene 24p3 Siderocalin p25

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
apoptotic process	IEA
innate immune response	ISS
siderophore transport	ISS
defense response to bacterium	IDA	27780864
positive regulation of cold-induced thermogenesis	ISS	20332347

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

iron coordination entity transport [inference]

siderophore transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
specific granule lumen	TAS
extracellular region	HDA ISS TAS	27068509
extracellular space	HDA IBA IDA	16502470 22664934 25645918 27780864
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183 33961781
identical protein binding	IPI	32296183
enterobactin binding	IDA	27780864 35101443
iron ion binding	IDA ISS	27780864
iron ion sequestering activity	IDA	27780864

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

ion binding [inference]

anion binding [inference]

enterobactin binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

macrolide binding [inference]

enterobactin binding

molecular sequestering activity [inference]

metal ion sequestering activity [inference]

iron ion sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lipocalin

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
small molecule binding

Displaying **all 3** entries
InterPro
Calycin
Lipocalin/cytosolic fatty-acid binding domain
Lipocalin

Disease

Disease Ontology

Displaying entries **1 - 10** of 26 in total

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DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0080784	urinary tract infection	Alliance of Genome Resources
DOID:0081292	traumatic brain injury	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:11111	hydronephrosis	Alliance of Genome Resources
DOID:13141	uveitis	Alliance of Genome Resources
DOID:13148	acute cystitis	Alliance of Genome Resources
DOID:1591	renovascular hypertension	Alliance of Genome Resources
DOID:1920	hyperuricemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16819		MGI:96757	MOUSE34232
Rattus norvegicus	170496		RGD:69408	RATNO28323
Pan troglodytes	464764	9598_0:002901		PANTR44922
Canis lupus familiaris	491320			CANLF19409
Bos taurus	526639			BOVIN03212
Sus scrofa	100153501			PIGXX16250
Oryctolagus cuniculus	100352980			RABIT17028
Pongo abelii	100444138	9601_0:002698		PONAB36204
Nomascus leucogenys	100599124			NOMLE36503
Loxodonta africana	100653544			LOXAF17048

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements