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lymphocyte cytosolic protein 1

Summary

Gene Symbol

LCP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3936

PubChem

3936

Alliance of Genome Resources

HGNC:6528

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Calcium
Cell junction
Cell membrane
Cell projection
Chromosomal rearrangement
Cytoskeleton
Direct protein sequencing
Disease variant
Metal-binding
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P13796	L-plastin LC64P Lymphocyte cytosolic protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
actin crosslink formation	ISS
animal organ regeneration	IEA
positive regulation of podosome assembly	IMP	24236012
actin filament network formation	IBA
extracellular matrix disassembly	IMP	24236012

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response

T cell activation [inference]

T cell activation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response

T cell activation [inference]

T cell activation involved in immune response

signal transduction [inference]

intracellular signal transduction [inference]

protein kinase A signaling

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization

cell motility [inference]

cell migration

wound healing, spreading of cells

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization

cellular component disassembly [inference]

extracellular matrix disassembly

cellular component assembly [inference]

actin filament bundle assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response

T cell activation [inference]

T cell activation involved in immune response

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport

regulation of protein transport [inference]

regulation of intracellular protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

protein kinase A signaling

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

regulation of organelle assembly [inference]

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

regulation of organelle assembly [inference]

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of podosome assembly [inference]

positive regulation of podosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of podosome assembly

positive regulation of protein-containing complex assembly [inference]

positive regulation of podosome assembly

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
cell junction	TAS
focal adhesion	IMP	16636079
ruffle membrane	IEA
plasma membrane	IDA
actin filament	IBA IMP ISS	16636079

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cell junction

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

ruffle membrane

actin filament bundle

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

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GO Term	Evidence Code	PMID
actin binding	NAS	2252891
integrin binding	IPI	20183869
actin filament binding	IBA IMP ISS	16636079
GTPase binding	IPI	24337748
identical protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

enzyme binding [inference]

GTPase binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Fimbrin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
actin binding
actin filament binding
actin filament network formation

Displaying **all 4** entries
InterPro
Actinin-type actin-binding domain, conserved site
CH domain superfamily
Calponin homology domain
Fimbrin/Plastin

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18826		MGI:104808	MOUSE13450
Danio rerio	30583		ZFIN:ZDB-GENE-991213-5	DANRE45565
Drosophila melanogaster	32721		FB:FBgn0024238
Rattus norvegicus	306071		RGD:1308288	RATNO09660
Xenopus laevis	379911		Xenbase:XB-GENE-962211
Pan troglodytes	452583	9598_0:00399d		PANTR07723
Canis lupus familiaris	476921			CANLF08694
Bos taurus	540990			BOVIN03646
Xenopus tropicalis	548438		Xenbase:XB-GENE-962206
Macaca mulatta	703429			MACMU16547