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MIRAGE

cerberus 1, DAN family BMP antagonist

Summary

Gene Symbol

cer1

Organism

Xenopus tropicalis (tropical clawed frog)

External Links

NCBI Gene

394437

PubChem

394437

Alliance of Genome Resources

Xenbase:XB-GENE-484971

Annotation

Keyword

Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Neurogenesis
Reference proteome
Secreted
Signal
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07G34	tCerberus

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
regionalization	IEA
cell surface receptor signaling pathway	ISS
nervous system development	ISS
nervous system development	IEA
heart development	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

signal transduction involved in regulation of gene expression

cellular developmental process [inference]

cell differentiation

multicellular organismal process [inference]

pattern specification process [inference]

regionalization

axis specification [inference]

anterior/posterior axis specification

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry [inference]

determination of heart left/right asymmetry

developmental process [inference]

anatomical structure development [inference]

animal organ development

heart development

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

localization [inference]

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in extracellular region [inference]

sequestering of BMP in extracellular matrix

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

signal transduction involved in regulation of gene expression

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

regulation of activin receptor signaling pathway [inference]

negative regulation of activin receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular regulation of signal transduction [inference]

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

sequestering of BMP in extracellular matrix

negative regulation of activin receptor signaling pathway

extracellular negative regulation of signal transduction [inference]

sequestering of extracellular ligand from receptor [inference]

sequestering of BMP in extracellular matrix

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	IEA
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
morphogen activity	IBA
Wnt-protein binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

morphogen activity

Wnt-protein binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

morphogen activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

morphogen activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cerberus

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
animal organ development
determination of heart left/right asymmetry
negative regulation of activin receptor signaling pathway
regionalization

Displaying **all 4** entries
InterPro
Cerberus
Cystine knot, C-terminal
Cystine-knot cytokine
DAN

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	9350	Xenbase:XB-GENE-865019
Danio rerio	12622	ZFIN:ZDB-GENE-040421-2
Danio rerio	23863	ZFIN:ZDB-GENE-040421-2
Danio rerio	199699	ZFIN:ZDB-GENE-040421-2
Xenopus laevis	394437	Xenbase:XB-GENE-865019
Xenopus laevis	398060	Xenbase:XB-GENE-865019

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025