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low density lipoprotein receptor

Summary

Gene Symbol

LDLR

Organism

Homo sapiens (human)

External Links

NCBI Gene

3949

PubChem

3949

Alliance of Genome Resources

HGNC:6547

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cholesterol metabolism
Coated pit
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Golgi apparatus
Host cell receptor for virus entry
Host-virus interaction
LDL
Lipid transport
Lysosome
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P01130

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 46 in total

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GO Term	Evidence Code	PMID
retinoid metabolic process	IEA
negative regulation of receptor recycling	IDA	17452316
lipid metabolic process	TAS	10827173 6299582
endocytosis	TAS	12671190
receptor-mediated endocytosis	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

catabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis involved in cholesterol transport

phagocytosis

cellular metabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory [inference]

long-term memory

behavior [inference]

learning or memory [inference]

memory [inference]

long-term memory

plasma lipoprotein particle clearance

amyloid-beta clearance

amyloid-beta clearance by cellular catabolic process

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to stimulus [inference]

response to stress [inference]

response to caloric restriction

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to caloric restriction

response to endogenous stimulus [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to lipid [inference]

response to fatty acid [inference]

cellular response to fatty acid

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to oxygen-containing compound [inference]

response to fatty acid [inference]

cellular response to fatty acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis involved in cholesterol transport

phagocytosis

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport [inference]

phospholipid transport

sterol transport [inference]

cholesterol transport

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

import into cell [inference]

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis involved in cholesterol transport

phagocytosis

establishment of localization in cell [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of cellular catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

regulation of cellular catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein metabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

regulation of protein metabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of cholesterol metabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of protein metabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of signaling [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

negative regulation of signaling [inference]

negative regulation of receptor recycling

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

negative regulation of signaling [inference]

negative regulation of receptor recycling

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

positive regulation of inflammatory response

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

positive regulation of inflammatory response

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of glial cell differentiation [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of astrocyte differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of astrocyte activation [inference]

negative regulation of astrocyte activation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

regulation of cellular catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of glial cell differentiation [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of astrocyte differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of astrocyte activation [inference]

negative regulation of astrocyte activation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

regulation of astrocyte activation [inference]

negative regulation of astrocyte activation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of supramolecular fiber organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

regulation of low-density lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

regulation of astrocyte activation [inference]

negative regulation of astrocyte activation

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

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GO Term	Evidence Code	PMID
lysosome	IDA	15166224 17461796
early endosome	IDA	15166224 17461796
early endosome	IBA
late endosome	IDA	17461796
Golgi apparatus	IDA	17461796

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

endolysosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

endolysosome membrane

endosome membrane

endolysosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

plasma membrane region [inference]

somatodendritic compartment

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

apical part of cell

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	ISS
virus receptor activity	IEA
protease binding	IPI	22081141 22848640
low-density lipoprotein particle receptor activity	TAS	20005821
low-density lipoprotein particle receptor activity	IC	22848640

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

protease binding

clathrin binding [inference]

clathrin heavy chain binding

identical protein binding

exogenous protein binding [inference]

virus receptor activity

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding

low-density lipoprotein particle binding

cargo receptor activity [inference]

lipoprotein particle receptor activity [inference]

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Low-density lipoprotein receptor

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

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InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
LDL receptor-like superfamily
LDLR class B repeat
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
NOTCH1 EGF-like calcium-binding domain

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:12783	migraine without aura	Alliance of Genome Resources
DOID:13810	familial hypercholesterolemia	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3949	Xenbase:XB-GENE-962372
Drosophila melanogaster	7436	FB:FBgn0066101
Drosophila melanogaster	7804	FB:FBgn0066101
Mus musculus	16835	Xenbase:XB-GENE-962372	MOUSE63178
Drosophila melanogaster	22359	FB:FBgn0066101
Xenopus tropicalis	174116	Xenbase:XB-GENE-962372
Bos taurus	281276		BOVIN32642
Rattus norvegicus	300438	Xenbase:XB-GENE-962372	RATNO39967
Xenopus tropicalis	373644	Xenbase:XB-GENE-962372
Danio rerio	387529		DANRE31127

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements