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Guidelines

MIRAGE

ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)

Summary

Gene Symbol

FCN2

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 396881
KEGG Gene ID: ssc:396881
PubChem: 396881

Annotation

Keyword

Calcium
Collagen
Complement activation lectin pathway
Disulfide bond
Glycoprotein
Lectin
Metal-binding
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q29041	Collagen/fibrinogen domain-containing protein 2 Ficolin-B Ficolin-beta L-ficolin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
complement activation, lectin pathway

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, lectin pathway

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, lectin pathway

innate immune response [inference]

complement activation, lectin pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, lectin pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, lectin pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, lectin pathway

innate immune response [inference]

complement activation, lectin pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, lectin pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, lectin pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, lectin pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
collagen trimer
extracellular space	IEA	30032202
collagen-containing extracellular matrix	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 5** entries
GO Term	Evidence Code	PMID
antigen binding
signaling receptor binding
carbohydrate binding
metal ion binding
carbohydrate derivative binding

GO Hierarchy

molecular function

binding [inference]

antigen binding

protein binding [inference]

signaling receptor binding

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding

carbohydrate derivative binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ficolin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Fibrinogen-like, C-terminal

KEGG BRITE Database

Orthology

K10104

Name

ficolin

References

8576206

Ortholog

Displaying entries **1 - 10** of 49 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2219		HUMAN99190
Homo sapiens	2220		HUMAN99188
Mus musculus	14134		MOUSE31708
Rattus norvegicus	114091		RATNO27388
Pan troglodytes	464840		PANTR45203
Pan troglodytes	473087		PANTR45202
Bos taurus	497016		BOVIN03469
Canis lupus familiaris	608247		CANLF19316
Macaca mulatta	712405		MACMU13361
Macaca mulatta	712486		MACMU13365

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025