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endothelin 1

Summary

Gene Symbol

EDN1

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 396915
PubChem: 396915

Annotation

Keyword

Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal
Vasoconstrictor

Proteins

Displaying 1 entry
UniProt	Protein Name
P09558	Preproendothelin-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
regulation of vasoconstriction	IEA	22301074
positive regulation of protein localization to nucleus
regulation of systemic arterial blood pressure by endothelin	IEA	30032202
endothelin receptor signaling pathway
positive regulation of prostaglandin-endoperoxide synthase activity	IEA	30032202

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

endothelin receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

phasic smooth muscle contraction [inference]

vein smooth muscle contraction

vascular associated smooth muscle contraction [inference]

vein smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

vasoconstriction [inference]

vascular associated smooth muscle contraction [inference]

vein smooth muscle contraction

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by endothelin

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

endothelin receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by endothelin

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction

vasoconstriction [inference]

vascular associated smooth muscle contraction [inference]

vein smooth muscle contraction

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of prostaglandin-endoperoxide synthase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of prostaglandin-endoperoxide synthase activity

regulation of oxidoreductase activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of prostaglandin-endoperoxide synthase activity

regulation of prostaglandin-endoperoxide synthase activity [inference]

positive regulation of prostaglandin-endoperoxide synthase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endothelin A receptor binding	IEA	30032202
endothelin B receptor binding	IEA	30032202
hormone activity	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

neuropeptide receptor binding [inference]

bombesin receptor binding [inference]

receptor ligand activity [inference]

hormone activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Endothelin

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
endothelin A receptor binding
endothelin B receptor binding
hormone activity
intracellular calcium ion homeostasis
regulation of systemic arterial blood pressure by endothelin
regulation of vasoconstriction
vein smooth muscle contraction

Displaying **all 3** entries
InterPro
Endothelin-like toxin, conserved site
Endothelin-like toxin
Endothelin

Ortholog

Displaying entries **81 - 85** of 85 in total

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Species	Gene ID	OrthoDB
Phacochoerus africanus	125135979	41426_0:0035a5
Budorcas taxicolor	128056360	37181_0:002b95
Moschus berezovskii	129543632	68408_0:005089
Bubalus kerabau	129647416	346063_0:0014a3
Hippopotamus amphibius kiboko	130831329	575201_0:0038c6