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complement C3

Summary

Gene Symbol

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397072
PubChem: 397072

Annotation

Keyword

Cleavage on pair of basic residues
Complement alternate pathway
Complement pathway
Direct protein sequencing
Disulfide bond
Fatty acid metabolism
Glycoprotein
Inflammatory response
Phosphoprotein
Reference proteome
Secreted
Signal
Thioester bond

Proteins

Displaying 1 entry
UniProt	Protein Name
P01025

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
positive regulation of protein phosphorylation
fatty acid metabolic process
inflammatory response	IEA	22301074
complement activation	IEA	22301074 30032202
complement activation, alternative pathway

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response

complement activation, alternative pathway

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of cellular biosynthetic process [inference]

regulation of triglyceride biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of localization [inference]

regulation of lipid storage [inference]

positive regulation of lipid storage

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

regulation of lipid localization [inference]

positive regulation of lipid localization [inference]

positive regulation of lipid storage

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of lipid localization [inference]

positive regulation of lipid storage

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of cellular biosynthetic process [inference]

regulation of triglyceride biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074
extracellular space	IEA	22301074 30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endopeptidase inhibitor activity	IEA	22301074
protein binding	IEA	22301074
C5L2 anaphylatoxin chemotactic receptor binding

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

C5a anaphylatoxin chemotactic receptor binding [inference]

C5L2 anaphylatoxin chemotactic receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2-macroglobulin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
endopeptidase inhibitor activity

Displaying entries **1 - 10** of 11 in total

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InterPro
Alpha-2-macroglobulin, bait region domain
Alpha-2-macroglobulin, conserved site
Alpha-2-macroglobulin
Alpha-macroglobulin, receptor-binding domain superfamily
Alpha-macroglobulin, receptor-binding
Alpha-macroglobulin-like, TED domain
Alpha-macroglobulin-like, thiol-ester bond-forming region
Immunoglobulin-like fold
Macroglobulin domain MG3
Macroglobulin domain

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	718	HUMAN40171
Mus musculus	12266	MOUSE20351
Rattus norvegicus	24232	RATNO43749
Danio rerio	30491	DANRE18100
Bos taurus	280677	BOVIN32790
Danio rerio	321046	DANRE17781
Canis lupus familiaris	476728	CANLF07957
Danio rerio	494039	DANRE18476
Danio rerio	565074	DANRE18249
Macaca mulatta	703613	MACMU20797

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OrthoDB (Group)

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Acknowledgements