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gamma-glutamyltransferase 1

Summary

Gene Symbol

GGT1

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397095
KEGG Gene ID: ssc:397095
PubChem: 397095

Annotation

Keyword

Acyltransferase
Cell membrane
Disulfide bond
Glutathione biosynthesis
Glycoprotein
Hydrolase
Protease
Reference proteome
Signal-anchor
Transmembrane helix
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A4X1V1S5	Gamma-glutamyltransferase Gamma-glutamyltranspeptidase
P20735	Gamma-glutamyltransferase 1 Gamma-glutamyltranspeptidase 1 Leukotriene-C4 hydrolase
A0A5K1UGB8	Gamma-glutamyltransferase Gamma-glutamyltranspeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
regulation of immune system process	IEA	30032202
glutamate metabolic process
glutathione biosynthetic process
glutathione catabolic process	IEA	22301074 30032202
peptide modification	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

peptide modification

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

glutamate metabolic process

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide modification

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

catabolic process [inference]

organic substance catabolic process [inference]

glutathione catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

glutathione metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide modification

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

organic substance catabolic process [inference]

glutathione catabolic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
leukotriene-C(4) hydrolase
glutathione hydrolase activity	IEA	22301074 30032202
leukotriene C4 gamma-glutamyl transferase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

leukotriene C4 gamma-glutamyl transferase activity

hydrolase activity [inference]

peptidase activity [inference]

omega peptidase activity [inference]

threonine-type peptidase activity [inference]

glutathione hydrolase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

omega peptidase activity [inference]

threonine-type peptidase activity [inference]

glutathione hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gamma-glutamyltransferase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
glutathione catabolic process
glutathione hydrolase activity

Displaying **all 4** entries
InterPro
Gamma-glutamyltranspeptidase, large subunit, C-terminal domain
Gamma-glutamyltranspeptidase, small subunit
Gamma-glutamyltranspeptidase
Nucleophile aminohydrolases, N-terminal

KEGG BRITE Database

Orthology

K18592

Name

gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]

References

Rhea

RHEA:31563

H₂O + leukotriene C₄

L-glutamate + leukotriene D₄

Enzyme

3.4.19.14

PMID

RHEA:28807

H₂O + glutathione

L-glutamate + L-cysteinylglycine

Enzyme

3.4.19.13

PMID

RHEA:59468

H₂O + an S-substituted glutathione

an S-substituted L-cysteinylglycine + L-glutamate

Enzyme

3.4.19.13

PMID

RHEA:23904

an α-amino acid

5-L-glutamyl amino acid

Enzyme

2.3.2.2

PMID

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	2678	HUMAN59643
Mus musculus	14598	MOUSE02290
Rattus norvegicus	116568	RATNO22295
Danio rerio	393387	DANRE43083
Canis lupus familiaris	486400	CANLF10560
Danio rerio	569014	DANRE00166
Bos taurus	615582	BOVIN09965
Macaca mulatta	700936	MACMU02730
Macaca mulatta	707545	MACMU02760
Ciona intestinalis	100182976	CIOIN06323