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Guidelines

MIRAGE

dihydrolipoamide dehydrogenase

Summary

Gene Symbol

DLD

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397129
KEGG Gene ID: ssc:397129
PubChem: 397129

Annotation

Keyword

Acetylation
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
FAD
Flagellum
Mitochondrion
NAD
Nucleus
Oxidoreductase
Phosphoprotein
Redox-active center
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P09623	Dihydrolipoamide dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202
oxoglutarate dehydrogenase complex	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle enzyme complex [inference]

dihydrolipoyl dehydrogenase complex [inference]

oxoglutarate dehydrogenase complex

oxidoreductase complex [inference]

dihydrolipoyl dehydrogenase complex [inference]

oxoglutarate dehydrogenase complex

transferase complex [inference]

oxoglutarate dehydrogenase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
dihydrolipoyl dehydrogenase activity	IEA	22301074 30032202
flavin adenine dinucleotide binding	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [inference]

dihydrolipoyl dehydrogenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cellular response to oxidative stress
flavin adenine dinucleotide binding
nucleotide binding
oxidoreductase activity

Displaying **all 6** entries
InterPro
FAD/NAD(P)-binding domain superfamily
FAD/NAD(P)-binding domain
FAD/NAD-linked reductase, dimerisation domain superfamily
Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Pyridine nucleotide-disulphide oxidoreductase, class I
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

KEGG BRITE Database

Orthology

K00382

Name

dihydrolipoyl dehydrogenase [EC:1.8.1.4]

References

Rhea

NAD⁺

H⁺ + NADH

Enzyme

1.8.1.4

PMID

(R)-dihydrolipoamide + NAD⁺

H⁺ + NADH + (R)-lipoamide

Enzyme

1.8.1.4

PMID

13767908

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1738		HUMAN90774
Mus musculus	13382		MOUSE08536
Rattus norvegicus	298942		RATNO35450
Danio rerio	399479		DANRE27563
Canis lupus familiaris	403978		CANLF05526
Pan troglodytes	463861		PANTR41163
Bos taurus	533910		BOVIN27962
Macaca mulatta	700494		MACMU32777
Equus caballus	100050920		HORSE33518
Ornithorhynchus anatinus	100078688		ORNAN05211

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025