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MIRAGE

N-acetylneuraminate pyruvate lyase

Summary

Gene Symbol

NPL

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397141
KEGG Gene ID: ssc:397141
PubChem: 397141

Annotation

Keyword

Carbohydrate metabolism
Cytoplasm
Direct protein sequencing
Lyase
Reference proteome
Schiff base

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8D0RDD8	N-acetylneuraminate pyruvate-lyase N-acetylneuraminic acid aldolase Sialate lyase Sialate-pyruvate lyase Sialic acid aldolase Sialic acid lyase
Q9BEC7	N-acetylneuraminate pyruvate-lyase N-acetylneuraminic acid aldolase Sialate lyase Sialate-pyruvate lyase Sialic acid aldolase Sialic acid lyase
A0A481AUE8	N-acetylneuraminate pyruvate-lyase N-acetylneuraminic acid aldolase Sialate lyase Sialate-pyruvate lyase Sialic acid aldolase Sialic acid lyase
A0A8D1C297	N-acetylneuraminate pyruvate-lyase N-acetylneuraminic acid aldolase Sialate lyase Sialate-pyruvate lyase Sialic acid aldolase Sialic acid lyase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA	22301074
N-acetylneuraminate catabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate catabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate catabolic process

organonitrogen compound catabolic process [inference]

N-acetylneuraminate catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

N-acetylneuraminate catabolic process

organonitrogen compound catabolic process [inference]

N-acetylneuraminate catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate catabolic process

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate catabolic process

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate catabolic process

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate catabolic process

amino sugar catabolic process [inference]

N-acetylneuraminate catabolic process

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

N-acetylneuraminate catabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate catabolic process

organonitrogen compound catabolic process [inference]

N-acetylneuraminate catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

carbohydrate derivative catabolic process [inference]

amino sugar catabolic process [inference]

N-acetylneuraminate catabolic process

organonitrogen compound catabolic process [inference]

N-acetylneuraminate catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process [inference]

N-acetylneuraminate catabolic process

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

N-acetylneuraminate catabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
N-acetylneuraminate lyase activity	IEA	22301074 30032202
4-hydroxy-tetrahydrodipicolinate synthase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

oxo-acid-lyase activity [inference]

N-acetylneuraminate lyase activity

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

4-hydroxy-tetrahydrodipicolinate synthase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

N-acetylneuraminate lyase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
Gene Ontology
N-acetylneuraminate catabolic process
N-acetylneuraminate lyase activity
lyase activity

Displaying **all 2** entries
InterPro
Aldolase-type TIM barrel
DapA-like

KEGG BRITE Database

Orthology

K01639

Name

N-acetylneuraminate lyase [EC:4.1.3.3]

References

Rhea

aceneuramate

pyruvate + N-acetyl-D-mannosamine

Enzyme

4.1.3.3

PMID

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026