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colony stimulating factor 2

Summary

Gene Symbol

CSF2

Organism

Sus scrofa (pig)

External Links

NCBI Gene: 397208
PubChem: 397208

Annotation

Keyword

Cytokine
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q29118	Colony-stimulating factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
immune response	IEA	22301074 30032202
myeloid cell differentiation	IEA	30032202
TOR signaling
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of ERK1 and ERK2 cascade

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type I interferon production [inference]

interferon-tau production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type I interferon production [inference]

interferon-tau production

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type I interferon production [inference]

interferon-tau production

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type I interferon production [inference]

interferon-tau production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type I interferon production [inference]

interferon-tau production

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

TOR signaling

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type I interferon production [inference]

interferon-tau production

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

multicellular organismal process [inference]

cytokine production [inference]

type I interferon production [inference]

interferon-tau production

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of trophectodermal cell proliferation [inference]

positive regulation of trophectodermal cell proliferation

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of trophectodermal cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of trophectodermal cell proliferation [inference]

positive regulation of trophectodermal cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

TOR signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of trophectodermal cell proliferation

regulation of trophectodermal cell proliferation [inference]

positive regulation of trophectodermal cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of trophectodermal cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074 30032202
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity	IEA	30032202
granulocyte macrophage colony-stimulating factor receptor binding	IEA	22301074 30032202
growth factor activity	IEA	22301074 30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

granulocyte macrophage colony-stimulating factor receptor binding

receptor ligand activity [inference]

growth factor receptor binding [inference]

granulocyte macrophage colony-stimulating factor receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

granulocyte-macrophage colony-stimulating factor

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cytokine activity
granulocyte macrophage colony-stimulating factor receptor binding
growth factor activity
immune response
myeloid cell differentiation

Displaying **all 2** entries
InterPro
Four-helical cytokine-like, core
Granulocyte-macrophage colony-stimulating factor

Ortholog

Displaying entries **1 - 10** of 51 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	1437	HUMAN80641
Mus musculus	12981	MOUSE05421
Rattus norvegicus	116630	RATNO00137
Bos taurus	281095	BOVIN33026
Canis lupus familiaris	403923	CANLF02081
Ovis aries	443400	SHEEP16505
Pan troglodytes	471627	PANTR36106
Felis catus	493805	FELCA02162
Macaca mulatta	574371	MACMU37808
Equus caballus	100033981	HORSE08749